国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 129-132.doi: 10.3760/cma.j.issn.1673422X.2017.02.013

• 综述 • 上一篇    下一篇

肿瘤放疗增敏药物新靶点

王艳俊,蒋永新,刘珊,王红   

  1. 650118 昆明医科大学第三附属医院教学管理科（王艳俊、蒋永新、王红），中西医科（刘珊）；云南省中西医结合肿瘤临床研究中心（王艳俊、蒋永新、刘珊、王红）
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 蒋永新，Email: 598104374@qq.com E-mail:598104374@qq.com

Novel drug targets in radiosensitivity of neoplasms

Wang Yanjun, Jiang Yongxin, Liu Shan, Wang Hong   

  1. Department of Teaching Management, Third Affiliated Hospital of Kunming Medical University; Tumor Clinical Research Center Combined Traditional Chinese and Western Medicine, Kunming 650118, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Jiang Yongxin E-mail:598104374@qq.com

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被引次数

1

摘要： 近期研究发现了一些对正常组织有保护作用而对病灶有放疗增敏作用的潜在有价值的药物靶点，包括氧自由基清除剂、针对DNA损伤修复和细胞周期的药物靶点、抑制细胞死亡新靶点、由生长因子介导的辐射防护、细胞信号通路的调节、血管紧张素转换酶抑制剂、辐射缓解剂等。

关键词: 肿瘤, 放射疗法, 辐射增敏药

Abstract: Recent studies find a number of promising drug targets which can be applied for increasing tumor radiosensitivity in addition to normal tissue radioprotection, including oxygen free radical scavenger, drug targets in view of DNA damage repair and cell cycle, new targets inhibiting cell death, radioprotection mediated by growth factors, regulation of the cell signaling pathways, angiotensinconverting enzyme inhibitor, radiorestorative chemicals and so on.

Key words: Neoplasms, Radiotherapy, Radiationsensitizing agents