国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (12): 944-947.doi: 10.3760/cma.j.issn.1673-422X.2017.12.016

• 综述 • 上一篇    下一篇

直肠癌术前放化疗的敏感性预测及临床应用

严雪绮,周俊东,吴锦昌   

  1. 周俊东，Email： zhoujundong330@163.com
  • 出版日期:2017-12-08 发布日期:2017-12-01
  • 通讯作者: 周俊东，Email： zhoujundong330@163.com E-mail:zhoujundong330@163.com
  • 基金资助:
    江苏省“六大人才高峰”项目（WSN-095）；江苏省第五期“333工程”科研项目（BRA2016071）

Sensitivity prediction of preoperative chemoradiotherapy in patients with rectal cancer and the clinical application

Yan Xueqi, Zhou Jundong, Wu Jinchang   

  1. Department of Radiation Oncology, Suzhou Hospital Afiliated to Nanjing Medical University, Suzhou 215000, China
  • Online:2017-12-08 Published:2017-12-01
  • Contact: Zhou Jundong, Email: zhoujundong330@163.com E-mail:zhoujundong330@163.com
  • Supported by:
    Six Talent Peaks Project Foundation of Jiangsu Province of China (WSN-095); Fifth "333 Project" Research Project Foundation of Jiangsu Province of China (BRA2016071)

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摘要： 部分直肠癌患者对术前同步放化疗（CCRT）敏感性较差，对CCRT治疗抵抗的患者，肿瘤的局部控制效果差，且CCRT可能增加不良反应。临床上通过应用核磁共振、正电子发射断层摄影技术、血清癌胚抗原、分子标志物和基因检测等方法，在治疗前对直肠癌患者CCRT的敏感性进行预测。根据预测结果指导临床医生为患者选择个体化治疗方式，从而使直肠癌的治疗效果得到进一步的提高。

关键词: 直肠肿瘤, 术前同步放化疗, 分子标志物

Abstract: Some of the patients with rectal cancer are less sensitive to preoperative concurrent chemoradiotherapy (CCRT). Patients who are resistant to CCRT have a poor local tumor control and CCRT may also increase adverse reactions. The sensitivity of rectal cancer patients to CCRT can be predicted by magnetic resonance imaging (MRI), positron emission tomography, serum carcinoembryonic antigen, molecular biomarkers and gene expression profiling before treatment. According to the predicted results, the clinicians are instructed to choose individualized treatment for the patients so that the therapeutic effects of rectal cancer are further improved.

Key words: Rectal neoplasms, Preoperative concurrent chemoradiotherapy, Molecular markers