国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (12): 911-913.doi: 10.3760/cma.j.issn.1673-422X.2017.12.007

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长非编码RNA UCA1作为竞争性内源RNA在调控肿瘤 发生发展中的作用

顾漱溟,徐岷   

  1. 212000 镇江，江苏大学附属医院消化内科
  • 出版日期:2017-12-08 发布日期:2017-12-01
  • 通讯作者: 徐岷，Email： peterxu1974@163.com E-mail: peterxu1974@163.com
  • 基金资助:
    国家自然科学基金(81672402)；江苏省高层次卫生人才“六个一工程”(LGY2016054)

Role of long non-coding RNA urothelial carcinoma associated antigen 1 as a competing endogenous RNA in the regulation of the initiation and progression of tumor

Gu Shuming, Xu Min.   

  1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China
  • Online:2017-12-08 Published:2017-12-01
  • Contact: Xu Min, Email： peterxu1974@163.com E-mail: peterxu1974@163.com
  • Supported by:
    National Natural Science Foundation of China (81672402); "Six Ones Program"of High-level Health Talents of Jiangsu Province (LGY2016054)

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摘要： 【摘要】长非编码RNA尿路上皮癌抗原1(UCA1)在膀胱癌、乳腺癌、结直肠癌等多种肿瘤中均呈高表达。近年来的研究表明，UCA1可以作为一种竞争性内源RNA（ceRNA）吸附微小RNA，间接调节靶基因表达水平，进而参与调控肿瘤的发生发展。因此，利用ceRNA作用机制干预UCA1的表达，将为肿瘤的治疗提供新思路。

关键词: 肿瘤, 长非编码RNA, 尿路上皮癌抗原1, 竞争性内源RNA

Abstract: Long non-coding RNA urothelial carcinoma associated antigen 1 (UCA1) is highly expressed in multiple types of tumors, such as bladder cancer, breast cancer, colorectal cancer and so on. Recent studies show that UCA1 can interact with the microRNAs as a competing endogenous RNA (ceRNA), to indirectly regulate the expression of target genes, and then participates in the regulation of the initiation and progression of tumor. Therefore, using the mechanism of ceRNA to intervene the expression of UCA1 will provide new ideas for tumor treatment.

Key words: Neoplasms, Long non-coding RNA, Urothelial carcinoma associated antigen 1, Competing endogenous RNA