国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 676-680.doi: 10.3760/cma.j.issn.1673422X.2016.09.009

• 综述 • 上一篇    下一篇

细胞焦亡、炎性体与肿瘤的关系

王静霞, 郭晓冬   

  1. 200433 上海中医药大学附属岳阳中西结合医院肿瘤科
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 郭晓冬，Email: gxd_1996@hotmail.com E-mail:gxd_1996@hotmail.com
  • 基金资助:

    国家自然科学基金（81102696）

Relationship among pyroptosis, inflammasome and tumor

Wang Jingxia， Guo Xiaodong   

  1. Department of Oncology，Yueyang Hosptail of Integrated Traditional Chinese and Western Medicine， Shanghai University of Traditional Chinese Medicine， Shanghai 200433， China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Guo Xiaodong E-mail:gxd_1996@hotmail.com
  • Supported by:

    Natural Science Foundation of China (81102696)

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摘要： 细胞焦亡是一种新的细胞程序性死亡的方式，多项研究显示其与多种疾病相关。炎性体、半胱天冬酶（caspase）在细胞焦亡的过程中扮演重要的角色。外来刺激使细胞内模式识别受体寡聚化，与凋亡相关微粒蛋白及caspase前体装配成炎性复合体，从而激活caspase诱导肿瘤细胞焦亡发生。而作为焦亡的上游调控机制，炎性体在肿瘤的生长中起着“双刃剑”的作用。一方面炎性体可以诱导肿瘤细胞发生焦亡，抑制肿瘤细胞的增殖；另一方面，炎性体的累积效应，也可以形成适宜肿瘤细胞生长的微环境，起着促瘤生长的作用。

关键词: 肿瘤, 细胞焦亡

Abstract: Pyroptosis is a new way of programmed cell death, a number of researches have found that it is associated with a variety of diseases. Inflammasome and caspase protein family play key roles in regulating pyroptosis.Intracellular pattern recognition receptor oligomers under external stimulus, then assemble with apoptotic specklike protein containing a caspase recruitment domain and caspase precursor into inflammatory complex body,thus activation of caspase can induce pyroptosis. While as the upstream regulation mechanism of pyroptosis,inflammasome might be "double edged sword" for tumor growth.On the one hand, inflammasome can inhibit the proliferation of tumor cells by inducing pyroptosis; on the other hand, the cumulative effect of the inflammsome can also form a suitable microenvironment for tumor cells and promote tumor growth.

Key words: Neoplasms, Pyroptosis