国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 673-675.doi: 10.3760/cma.j.issn.1673422X.2016.09.008

• 综述 • 上一篇    下一篇

SPARCL1基因在肿瘤中的表达及作用

赵书杰, 周栋   

  1. 213003 南京医科大学附属常州市第二人民医院骨科
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 周栋，Email: zhoudong1012@hotmail.com E-mail:zhoudong1012@hotmail.com

Expression and role of SPARCL1 gene in tumor

Zhao Shujie, Zhou Dong   

  1. Department of Orthopedics, Second People′s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Zhou Dong E-mail:zhoudong1012@hotmail.com

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摘要： 富含半胱氨酸的酸性分泌蛋白类似蛋白1（SPARCL1）基因的异常表达与多种肿瘤的发展、转移及预后密切相关。近年来研究表明，SPARCL1基因在脑胶质瘤中表达升高，其编码的蛋白可以和胶原相互作用，从而影响肿瘤的转移能力，与肿瘤恶性程度呈正相关。SPARCL1基因在胃癌、结直肠癌、前列腺癌及乳腺癌等肿瘤组织中低表达，与肿瘤的侵袭及转移能力呈负相关。目前对于SPARCL1基因发挥作用的具体分子机制仍存在争议，其在肿瘤组织中的表达和功能似乎依赖于肿瘤微环境。

关键词: 肿瘤, 肿瘤转移, 富含半胱氨酸的酸性分泌蛋白类似蛋白1基因

Abstract: 【Abstract】Abnormal expression of secreted protein acidic and rich in cysteine like 1 (SPARCL1) gene is closely related to the development, metastasis and prognosis of a variety of tumors. Recent studies show that SPARCL1 gene is high expressed in glioma. The protein product of SPARCL1 gene encoded can interact with collagen, thus affecting the metastasis ability of tumor, which is positively correlated with tumor malignant degree. SPARCL1 gene is low expressed in gastric cancer, colorectal cancer, prostate cancer and breast cancer, which is negatively correlated with the invasion and metastasis abilities of tumors. At present, the role of specific molecular mechanisms of SPARCL1 gene remains controversial. The expressions and functions of SPARCL1gene in tumor tissues seem to depend on the tumor microenvironment.

Key words: Neoplasms, Neoplasm metastasis, Secreted protein acidic and rich in cysteine like 1 gene