基质金属蛋白酶-9与结直肠癌

doi:10.3760/cma.j.issn.1673422X.2016.07.015

摘要/Abstract

摘要： 基质金属蛋白酶（MMP）能够降解细胞外基质，对肿瘤生长、侵袭和扩散至关重要。作为MMP家族中相对分子质量最大的，MMP-9参与结直肠癌的生成和进展。研究显示MMP-9可用于结直肠癌患者的早期诊断，组织和血浆中MMP-9表达水平与结直肠癌患者术后预后呈负相关。另外，针对MMP-9在结直肠癌组织中表达增加这一特点可设计相关的靶向治疗药物。

关键词: 基质金属蛋白酶9, 结直肠肿瘤, 诊断, 预后, 治疗

Abstract: Matrix metalloproteinase (MMP) plays an important role in the degradation of extracellular matrix components, which is crucial for tumor growth, invasion and metastasis. As one with the largest relative molecular mass in MMP family, MMP9 takes part in the generation and progression of colorectal cancer. Research shows that MMP9 can be used for the early diagnosis of colorectal cancer. The expression levels of MMP9 in tissue and plasma are negatively correlated with prognosis of the postoperative patients with colorectal cancer. In addition, targeted therapy drugs will be designed on the basis of MMP9 expression increased in colorectal cancer.

Key words: Matrix metalloproteinase 9, Colorectal , neoplasms, Diagnosis, Prognosis, Therapy

程欣, 黄颖, 刘宁. 基质金属蛋白酶-9与结直肠癌[J]. 国际肿瘤学杂志, 2016, 43(7): 538-540.

Cheng-Xin, HUANG Ying, LIU Ning. Matrix metalloproteinase and colorectal cancer[J]. Journal of International Oncology, 2016, 43(7): 538-540.

参考文献

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