国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (3): 226-228.doi: 10.3760/cma.j.issn.1673422X.2016.03.018

• 综述 • 上一篇    下一篇

RNA结合蛋白Musashi1在结直肠癌中的表达及临床意义

丁博月,韩春,高超   

  1. 050011 石家庄，河北医科大学第四医院放疗科
  • 出版日期:2016-03-08 发布日期:2016-02-03
  • 通讯作者: 韩春，Email: hanchun2006@126.com E-mail:hanchun2006@126.com

Expression and clinical significance of RNA-binding protein Musashi1 in colorectal cancer

Ding Boyue, Han Chun， Gao Chao   

  1. Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • Online:2016-03-08 Published:2016-02-03
  • Contact: Han Chun, Email: hanchun2006@126.com E-mail:hanchun2006@126.com

PDF

1369

摘要： Musashi1（Msi1）是一种进化保守的RNA结合蛋白，同时它是肠道、神经等多种组织中的干细胞标志物，对于维持自我更新与分化之间的平衡具有重要作用。近年来研究发现Msi1在多种肿瘤组织尤其是结直肠癌中高表达，参与调控细胞周期、增殖、凋亡等过程，逐渐成为多种癌变的关键调节剂，有望成为肿瘤治疗的新靶点。

关键词: 结直肠肿瘤, RNA结合蛋白类, Musashi1

Abstract: Musashi1 (Msi1) is an evolutionary conservative RNA-binding protein (RBP), and it is a stem  marker in a variety of organizations, including intestinal, neural system. Msi1 maintains the balance between selfrenewal and differentiation. Recently, many researchers report that Msi1 is overexpressed in many types of tumors， especially in colorectal neoplasms, participating in the regulation of cell cycle, proliferation, apoptosis and so on. Msi1 becomes a key regulator of many cancers, which is expected to turn into a new target for cancer therapy.

Key words: Colorectal neoplasms, RNA-binding proteins, Musashi1