国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (2): 119-.

• 综述 • 上一篇    下一篇

核仁素与肿瘤生物学行为的关系

王晓, 高勇, 李砚东   

  1. 大连医科大学附属上海市东方医院肿瘤血液科
  • 出版日期:2016-02-08 发布日期:2015-12-28

The correlation between nucleolin and biological behavior of tumor

WANG  Xiao, GAO  Yong, LI  Yan-Dong   

  1. Department of Oncology and Hematology, Shanghai East Hospital, Dalian Medical University, Shanghai 200120,China
  • Online:2016-02-08 Published:2015-12-28

摘要: 核仁素的异常表达存在于多种疾病进展中,特别会影响炎症反应、病毒感染、肿瘤等疾病的发生和进展。核仁素在多种肿瘤中表达量升高,分布位置发生变化,影响肿瘤细胞增殖、凋亡、肿瘤转移等多个过程。

关键词: 肿瘤, 细胞增殖, 凋亡体, 肿瘤转移

Abstract: Nucleolin is implicated in many pathological processes, particularly in inflammatory diseases, viral infection and neoplasms. Nucleolin levels are increased in several neoplasms and its localization changed, which play important roles in cell proliferation, apoptosis and metastasis of neoplasms.

Key words: Neoplasms, Cell proliferation, Apoptosomes, Neoplasm metastasis