微小RNA-449在肿瘤中的作用及其调控机制

摘要/Abstract

摘要： 超过50%的微小RNA(miRNA)定位于肿瘤相关的基因组扩增区域或脆性位点，可具有癌基因或抑癌基因的功能。近年来研究显示，在人类胃癌、肺癌、卵巢癌等恶性肿瘤中miR449表达降低，被认为是一个抑癌miRNA。miR449表达异常可能与肿瘤的发生和发展过程密切相关，研究其功能及调控机制，可为肿瘤诊断、治疗和预后判断提供重要线索。

关键词: 肿瘤, 基因调控网络, 微小RNA-449

Abstract: More than 50% microRNAs (miRNAs) are located in tumorassociated genome of amplification region or fragile site, which may also act as oncogenes or tumor suppressor gene (TSG). Recently, researches show that the expression of miR449 is lower in human gastric, lung and ovarian cancer, and may act as TSG. The abnormal expression of miR449 plays a pivotal role in carcinogenesis and progression, and elucidating its function and regulatory mechanism can provide valuable diagnostic, prognostic biomarker for cancer management.

Key words: Neoplasms, Gene regulatory networks, microRNA-449

王小利, 常永超, 刘刚. 微小RNA-449在肿瘤中的作用及其调控机制[J]. 国际肿瘤学杂志, 2016, 43(2): 110-.

WANG Xiao-Li, CHANG Yong-Chao, LIU Gang. Role and regulatory mechanism of microRNA449 in cancer[J]. Journal of International Oncology, 2016, 43(2): 110-.

参考文献

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