国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (12): 921-923.doi: 10.3760/cma.j.issn.1673422X.2016.12.010

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ABCA1：肿瘤治疗新靶点

熊婷, 黄雪龙, 陆凯强, 刘晓旺, 谢伟全, 陈洪飞, 涂剑   

  1. 南华大学药物药理研究所
  • 出版日期:2016-12-08 发布日期:2016-11-02
  • 基金资助:

    国家自然科学基金（81541163）；湖南省自然科学基金（2015JJ3101）；湖南省教育厅开放基金（15K111）；“湖南省分子靶标新药研究协同创新中心”培育项目（2014405）；南华大学分子靶标新药协同创新中心研究生创新项目（D223000200028）

ABCA1: a new therapeutic target of tumor

XIONG  Ting, HUANG  Xue-Long, LU  Kai-Qiang, LIU  Xiao-Wang, XIE  Wei-Quan, CHEN  Hong-Fei, TU  Jian   

  1. Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China
  • Online:2016-12-08 Published:2016-11-02
  • Supported by:

    National Natural Science Foundation of China (81541163); Natural Science Foundation of Hunan Province of China (2015JJ3101); Open Fund Based on Innovation Platform of Hunan Provincial Education Department (15K111); Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study (2014405); Innovation Program of Graduate Education in Cooperative Innovation Center for Molecular Target New Drug of University of South China（D223000200028）

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摘要： 三磷酸腺苷结合盒转运体A1(ABCA1)是三磷酸结合盒转运体超家族的重要成员之一，在胆固醇逆向转运、胆固醇代谢以及高密度脂蛋白(HDL)代谢中起着极其重要的调节作用。ABCA1基因突变会诱导Tangier疾病和家族型HDL缺乏。近年来研究表明ABCA1介导的胆固醇流出功能具有抗肿瘤活性，ABCA1有望成为肿瘤治疗新靶点。

关键词: 肿瘤, 胆固醇, 三磷酸腺苷结合盒转运体A1

Abstract: ATPbinding cassette transporter A1 is one of the important members of the ABC transporter protein family, which plays a very crucial role in cholesterol reverse transport, cholesterol metabolism and the regulation of highdensity lipoprotein (HDL) metabolism. Mutation of ABCA1 gene could induce Trangier disease and familial deficiency of HDL. Recent studies have pointed out that ABCA1 could have anticancer activity through cholesterol efflux, which will become a promising new therapeutic target of tumor.

Key words: Neoplasms, Cholesterol, ATPbinding cassette transporter A1