白藜芦醇用于预防和治疗结直肠癌的研究进展

doi:10.3760/cma.j.issn.1673-422X.2016.01.019

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (1): 67-70.doi: 10.3760/cma.j.issn.1673-422X.2016.01.019

白藜芦醇用于预防和治疗结直肠癌的研究进展

徐家辉,刘德英,许志军,马文霞,张庆玲

510515 广州，南方医科大学第一临床医学院（徐家辉、刘德英、许志军），基础医学院病理学系（马文霞、张庆玲）；南方医科大学南方医院病理科（张庆玲）

收稿日期:2015-05-18 出版日期:2016-01-08 发布日期:2015-12-03
通讯作者: 张庆玲 E-mail:zqllc8@126.com
基金资助:
国家自然科学基金（81272760、81472712）；广东省科技计划（c1221020700008）

Research progress of resveratrol on the prevention and treatment of colorectal cancer

Xu Jiahui, Liu Deying, Xu Zhijun, Ma Wenxia, Zhang Qingling

First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China

Received:2015-05-18 Online:2016-01-08 Published:2015-12-03
Contact: Zhang Qingling E-mail:zqllc8@126.com
Supported by:
National Natural Science Foundation of China (81272760, 81472712); Science and Technology Program of Guangdong Province of China (c1221020700008)

摘要/Abstract

摘要： 近年来研究显示，白藜芦醇具有抗氧化、抗炎的特性，能够调节细胞内糖和神经酰胺的代谢，激活转录激活因子3和过氧化物酶体增殖物激活受体γ等抑癌因子，又可下调鼠类肉瘤病毒癌基因的表达，抑制癌细胞上皮间质转化的发生等，使得白藜芦醇在预防和治疗结直肠癌方面发挥重要作用。另外，白藜芦醇在联合治疗中显示出广阔的应用前景。

关键词: 结直肠肿瘤, 白藜芦醇

Abstract: Recent studies show that resveratrol is characterized with its antioxidative and antiinflammatory effects, and plays an important role in the prevention and treatment of colorectal cancer through modulating intracellular carbohydrate and ceramide metabolism, activating tumor suppressors such as activator of transcription 3 and peroxisome proliferatorsactivated receptor γ, downregulating the expression of kirsten rat sarcoma viral oncogene and inhibiting the epithelialtomesenchymal transition process of cancer cells. In addition, resveratrol exhibits its broad application prospects in combination therapy.

Key words: Colorectal neoplasms, Resveratrol

徐家辉,刘德英,许志军,马文霞,张庆玲. 白藜芦醇用于预防和治疗结直肠癌的研究进展[J]. 国际肿瘤学杂志, 2016, 43(1): 67-70.

Xu Jiahui, Liu Deying, Xu Zhijun, Ma Wenxia, Zhang Qingling. Research progress of resveratrol on the prevention and treatment of colorectal cancer[J]. Journal of International Oncology, 2016, 43(1): 67-70.

参考文献

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白藜芦醇用于预防和治疗结直肠癌的研究进展

Research progress of resveratrol on the prevention and treatment of colorectal cancer

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