长非编码RNA UCA1在肿瘤中的研究进展

doi:10.3760/cma.j.issn.1673-422X.2016.01.008

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (1): 29-31.doi: 10.3760/cma.j.issn.1673-422X.2016.01.008

长非编码RNA UCA1在肿瘤中的研究进展

史有阳,钱亚云

225009 扬州大学医学院中西医结合学系

收稿日期:2015-05-07 出版日期:2016-01-08 发布日期:2015-12-03
通讯作者: 钱亚云 E-mail:yyqian@yzu.edu.cn
基金资助:
国家自然科学基金（81403232、81450051）

Research progress of long non-coding RNA UCA1 in tumor

Shi Youyang, Qian Yayun

Department of Integrative Medicine, Medical School, Yangzhou University, Yangzhou 225009, China

Received:2015-05-07 Online:2016-01-08 Published:2015-12-03
Contact: Qian Yayun E-mail:yyqian@yzu.edu.cn
Supported by:
National Natural Science Foundation of China (81403232, 81450051)

摘要/Abstract

摘要： 作为一种原癌基因，尿路上皮癌抗原1（UCA1）在膀胱癌、胃癌、乳腺癌、卵巢癌、脑胶质瘤等多种肿瘤中均呈高表达，在肿瘤的诊断、治疗和预后中均显示出重要的应用价值。研究表明UCA1可通过多条信号通路和多种分子机制促进肿瘤细胞增殖，可能成为肿瘤诊断及治疗的潜在新靶点。

关键词: RNA, 肿瘤, 尿路上皮癌抗原1

Abstract: As a proto-oncogene, urothelial carcinoma antigen 1 (UCA1) is highly expressed in many human tumors such as bladder cancer, gastric cancer, breast cancer, ovarian cancer and brain glioma, which shows important application value in the diagnosis, treatment and prognosis of tumor. Studies show that UCA1 can promote tumor cell proliferation through multiple signaling pathways and molecular mechanisms, which may become a new potential target for the diagnosis and treatment of tumor.

Key words: RNA, Neoplasms, Urothelial carcinoma antigen 1

史有阳,钱亚云. 长非编码RNA UCA1在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2016, 43(1): 29-31.

Shi Youyang, Qian Yayun. Research progress of long non-coding RNA UCA1 in tumor[J]. Journal of International Oncology, 2016, 43(1): 29-31.

参考文献

［1］ Wang XS, Zhang Z, Wang HC, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladdercarcinoma［J］. Clin Cancer Res, 2006, 12 (16): 4851-4858. DOI:10.1158/10780432.CCR-06-0134. ［2］ Xue M, Li X, Wu W, et al. Upregulation of long noncoding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis［J］. Oncol Rep, 2014, 31(5): 1993-2000. DOI:10.3892/or.2014.3092. ［3］ Xie XJ, Li X, Wang F, et al. Cellular localization and tissue expression pattern of UCA1, a noncoding RNA［J］. Nan Fang Yi Ke DaXue Xue Bao, 2010, 30(1): 57-60. ［4］ Rafiee P, Shi Y, Su J, et al. Erythropoietin protects the infant heart against ischemiareperfusion injury by triggering multiple signaling pathways［J］. Basic Res Cardiol, 2005, 100(3): 187-197. ［5］ Codolo G, Munari F, Fassan M, et al. Evaluation of the efficacy of the H. pylori protein HPNAP as a therapeutic tool for treatment of bladder cancer in an orthotopic murine model［J］. J Vis Exp, 2015, 99: e52743. DOI:10.3791/52743. ［6］ Zhang Z, Hao H, Zhang CJ, et al. Evaluation of novel gene UCA1 as a tumor biomarker for the detection of bladder［J］. Zhonghua Yi Xue Za Zhi, 2012, 92(6): 384-387. ［7］ Wang F, Li X, Xie X, et al. UCA1, a nonproteincoding RNA upregulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion［J］. FEBS Letters, 2008, 582(13): 1919-1927. DOI:10.1016/j.febslet.2008.05.012. ［8］ Fan Y, Shen B, Tan M, et al. Long noncoding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling［J］. FEBS J, 2014, 281(7): 1750-1758. DOI:10.1111/febs.12737. ［9］ Yang C, Li X, Wang Y, et al. Long noncoding RNA UCA1 regulated cell cycle distribution via CREB through PI3K dependent pathway in bladder carcinoma cells［J］. Gene, 2012, 496(1): 8-16. DOI:10.1016/j.gene.2012.01.012. ［10］ Wang X, Gong X, Jin B, et al. Long noncoding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells［J］. Oncology Rep, 2014, 32(3): 1281-1290. DOI:10.3892/or.2014.3309. ［11］ Gu W, Gao T, Sun Y, et al. LncRNA expression profile reveals the potential role of lncRNAs in gastric carcinogenesis［J］. Cancer Biomark, 2015, 15(3): 249-258. DOI:10.3233/CBM-150460. ［12］ Han Y, Yang YN, Yuan HH, et al. UCA1, a long noncoding RNA upregulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution［J］. Pathology, 2014, 46(5): 396-401. DOI:10.1097/PAT.0000000000000125. ［13］ Li JY, Ma X, Zhang CB. Overexpression of long noncoding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma［J］. Int J Clin Exp Pathol, 2014, 7(11): 7938-7944. ［14］ Huang J, Zhou N, Watabe K, et al. Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)［J］. Cell Death Dis, 2014, 5：e1008. DOI:10.1038/cddis.2013.541. ［15］杨慧, 余敏敏, 陆晓媛. 长链非编码RNA在宫颈癌及宫颈上皮内瘤样病变中的表达［J］. 江苏医药, 2014, 40(22): 2685-2688. ［16］ Lim D, Olive E. Precursors and pathogenesis of ovarian carcinoma［J］. Pathology, 2013, 45(3): 229-242. DOI:10.1097/PAT.0b013e32835f2264. ［17］ Wang F, Zhou J, Xie X, et al. Involvement of SRPK1 in cisplatin resistance related to long noncoding RNA UCA1 in human ovarian cancer cells［J］. Neoplasma, 2015, 62(3): 432-438. DOI:10.4149/neo/2015/051. ［18］ Gerstner ER, Batchelor TT. Imaging and response criteria in gliomas［J］. Curr Opin Oncol, 2010, 22(6): 598-603. DOI:10.1097/CCO.0b013e32833de96e. ［19］孙阳. 长链非编码RNA在脑胶质瘤中差异表达的相关研究［D］. 长春: 吉林大学, 2014. ［20］ Tsang WP, Wong TW, Cheung AH, et al. Induction of drug resistance and transformation in human cancer cells by the noncodingRNA CUDR［J］. RNA, 2007, 13(6): 890-898. DOI:10.1261/rna.359007. ［21］ Tian Y, Zhang X, Hao Y, et al. Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma[J]. Melanoma Res, 2014, 24(4): 335-341. DOI:10.1097/CMR.0000000000000080. ［22］ Fang Z, Wu L, Wang L, et al. Increased expression of the long noncoding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis［J］. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(1): 8995. DOI:10.1016/j.oooo.2013.09.007.

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长非编码RNA UCA1在肿瘤中的研究进展

Research progress of long non-coding RNA UCA1 in tumor

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