MTH1基因在肿瘤发生及治疗中的作用

doi:10.3760/cma.j.issn.1673-422X.2016.01.007

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (1): 26-28.doi: 10.3760/cma.j.issn.1673-422X.2016.01.007

MTH1基因在肿瘤发生及治疗中的作用

管叙文,黄鼎智

300060 天津医科大学肿瘤医院消化肿瘤内科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室

收稿日期:2015-10-22 出版日期:2016-01-08 发布日期:2015-12-03
通讯作者: 黄鼎智 E-mail:dingzhih72@163.com
基金资助:
天津市自然科学基金（15JCYBJC28200）

Roles of MTH1 gene in the occurrence and treatment of cancers

Guan Xuwen, Huang Dingzhi

epartment of Gastroenterological Oncology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China

Received:2015-10-22 Online:2016-01-08 Published:2015-12-03
Contact: Huang Dingzhi E-mail:dingzhih72@163.com
Supported by:
Tianjin Municipal Natural Science Foundation (15JCYBJC28200)

摘要/Abstract

摘要： MTH1蛋白能通过水解氧化的脱氧核糖核苷三磷酸修复活性氧造成的DNA损伤，其在肿瘤细胞中高表达，并维持肿瘤细胞存活。MTH1基因与微小RNA、RAS、p53等肿瘤相关基因关系密切，且MTH1抑制剂可以选择性地抑制肿瘤细胞增殖，是一个极具潜力的肿瘤治疗新靶点。

关键词: 肿瘤, 活性氧, 靶向治疗

Abstract: MTH1 protein can mitigate DNA damage which caused by reactive oxygen species through hydrolyzing oxidized deoxyribonucleoside triphosphate. MTH1 is highly expressed in various cancers, so as to maintain the viability of cancer cells. MTH1 is closely related to tumor associated genes such as microRNA, RAS gene and p53 gene. Moreover, MTH1 inhibitors can selectively suppress the proliferation of cancers, which is a potential new target in tumor therapy.

Key words: Neoplasms, Reactive oxygen species, Targeted therapy

管叙文,黄鼎智. MTH1基因在肿瘤发生及治疗中的作用[J]. 国际肿瘤学杂志, 2016, 43(1): 26-28.

Guan Xuwen, Huang Dingzhi. Roles of MTH1 gene in the occurrence and treatment of cancers[J]. Journal of International Oncology, 2016, 43(1): 26-28.

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MTH1基因在肿瘤发生及治疗中的作用

Roles of MTH1 gene in the occurrence and treatment of cancers

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