国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (8): 645-647.doi: 10.3760/cma.j.issn.1673-422X.2014.09.002

• 综述 • 上一篇    下一篇

血小板在肿瘤生长和转移中的作用

张天嘉,党素英   

  1. 200025 上海交通大学口腔医学院(张天嘉)，医学遗传教研室（党素英）
  • 出版日期:2014-09-25 发布日期:2014-09-05
  • 通讯作者: 党素英 E-mail:uyingdang@shsmu.edu.cn
  • 基金资助:

    国家自然科学基金（81200352）；上海交通大学医学院RBL教学项目（2013B001）

Functions of platelets in tumor growth and metastasis

Zhang Tianjia, Dang Suying   

  1. College of Stomatology, Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2014-09-25 Published:2014-09-05
  • Contact: Dang Suying E-mail:uyingdang@shsmu.edu.cn

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摘要： 血小板的数量和活性增加与肿瘤转移相关，血小板主要通过促进免疫逃避、黏附作用以及血管生成参与肿瘤转移进程。最新研究显示血小板与肿瘤细胞间的直接相互作用对肿瘤的转移也具有重要的促进作用。血小板促进肿瘤进展和转移的作用提示血小板可以作为肿瘤治疗的新靶点。

关键词: 血小板, 肿瘤, 肿瘤转移

Abstract: Increases of platelet amount and activation are associated with tumor metastasis. Current studies reveal that platelets participate in the process of tumor metastasis via promoting immune escape, adhesion and angiogenesis. The direct interactions between platelets and tumor cells are also founded as an important determinant in metastasis. The functions of platelets in tumor progression and metastasis suggest that platelets could be served as new potential targets for cancer treatment.

Key words: Blood platelets, Neoplasms, Neoplasm metastasis