微透析技术在肿瘤中的应用

doi:10.3760/cma.j.issn.1673-422X.2014.08.004

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (8): 570-573.doi: 10.3760/cma.j.issn.1673-422X.2014.08.004

微透析技术在肿瘤中的应用

周静超,李娟,刘春生,周丁华,童卫杭,王丹

100088北京，中国人民解放军第二炮兵总医院药学部（周静超、童卫航、王丹），预防保健科（李娟），骨科（刘春生），肝胆外科（周丁华）

收稿日期:2014-03-06 修回日期:2014-04-18 出版日期:2014-08-15 发布日期:2014-08-14
通讯作者: 王丹，E-mail: wdyy_618@sina.com E-mail:wdyy_618@sina.com
基金资助:
国家自然科学基金（81301662）；中国博士后科学基金（2013M532151）

Application of microdialysis in tumor

Zhou Jingchao, Li Juan, Liu Chunsheng, Zhou Dinghua, Tong Weihang, Wang Dan

Department of Pharmacy, Second Artillery General Hospital of PLA, Beijing 100088, China

Received:2014-03-06 Revised:2014-04-18 Online:2014-08-15 Published:2014-08-14
Contact: Wang Dan E-mail:wdyy_618@sina.com

摘要/Abstract

摘要： 微透析技术是一种定向深入靶组织的自动生物取样技术。它可从分子水平上监测肿瘤病理生理学改变引起的靶组织药物及相关物质变化，用于评价肿瘤靶组织药物的药代动力学，优化联合用药，探究肿瘤的分子靶向治疗及进行肿瘤的早期诊断和预后，为肿瘤防治研究提供新的思路和方法。

关键词: 微透析, 肿瘤, 药代动力学, 诊断, 预后, 分子靶向治疗

Abstract: Microdialysis is an automatic biological sampling technique that is directed into the target tissue. Microdialysis is used to monitor the changes of drug and related substances associated with pathological physiology of tumor in the target tissue at the molecular level. Microdialysis is applied to evaluate the pharmacokinetics of drugs in the target tissue of tumor, optimize the combination therapy, explore molecular targeted therapy and study the early diagnosis and prognosis of tumor. Microdialysis provides a new idea and method for the prevention and cure research of tumor.

Key words: Microdialysis, Neoplasms, Pharmacokinetics, Diagnosis, Prognosis, Molecular targeted therapy

周静超,李娟,刘春生,周丁华,童卫杭,王丹. 微透析技术在肿瘤中的应用[J]. 国际肿瘤学杂志, 2014, 41(8): 570-573.

Zhou Jingchao, Li Juan, Liu Chunsheng, Zhou Dinghua, Tong Weihang, Wang Dan. Application of microdialysis in tumor[J]. Journal of International Oncology, 2014, 41(8): 570-573.

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微透析技术在肿瘤中的应用

Application of microdialysis in tumor

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