癌症相关性疲劳流行病学及发病机制研究进展

doi:10.3760/cma.j.issn.1673-422X.2014.03.008

摘要/Abstract

摘要： 癌症相关性疲劳(CRF)是与肿瘤和(或)抗肿瘤治疗相关的疲劳，发病率高，严重影响患者生活质量。病因包括心理、生理、社会等多种影响因素，目前存在多种发病机制假说，其中炎症机制假说可能在CRF的发生、发展中发挥重要作用，多种炎症细胞因子如白细胞介素（IL）-1β、IL-6、肿瘤坏死因子-α（TNF-α）、C反应蛋白(CRP)与CRF发病显著相关。

关键词: 肿瘤, 疲劳, 炎症, 细胞因子类

Abstract: Cancer-related fatigue (CRF) is associated with tumor and (or) antitumor treatment, which has a high incidence and seriously affects the life quality of patients. The etiology of CRF involves psychology, physiology and social factors. There are various hypothesis of pathogenesis and the inflammatory system may play an important role in the generation and development of CRF. A variety of inflammatory cytokines such as IL-1β, IL-6, TNF-α, CRP are significantly correlated with CRF.

Key words: Neoplasms, Fatigue, Inflammation, Cytokines

陈红姗, 王玉栋, 刘巍. 癌症相关性疲劳流行病学及发病机制研究进展[J]. 国际肿瘤学杂志, 2014, 41(3): 187-190.

CHEN Hong-Shan, WANG Yu-Dong, LIU Wei. Epidemiology and pathogenesis research progress of cancer-related fatigue[J]. Journal of International Oncology, 2014, 41(3): 187-190.

参考文献

［1］ Minton O, Berger A, Barsevick A, et al. Cancerrelated fatigue and its impact on functioning［J］. Cancer, 2013, 119Suppl11:21242130. ［2］ Bower JE, Lamkin DM. Inflammation and cancerrelated fatigue:Mechanisms,coutributing factors,and treatment implications［J］. Brain Behav Immun, 2013Suppl:S4857. ［3］ Tazi el M, Errihani H. Evaluation and management of fatigue in oncology:a multidimensional approach［J］.Indian J Palliat Care， 2011, 17(2):9297. ［4］ Berger AM, Gerber LH, Mayer DK. Cancerrelated fatigue:implications for breast cancer survivors［J］. Cancer, 2012,118(8Suppl):22612269. ［5］ Yun YH, Lee KS, Kim YW, et al. Webbased tailored deucation program for diseasefree cancer survivors with cancerrelated fatigue:a randomized controlled trial［J］. J Clin Oncol, 2012, 30(12):12961303. ［6］ Minton O, Stone P. A systematic review of the scales used for the measurement of cancerrelated fatigue (CRF)［J］. Ann Oncol, 2009, 20(1):1725. ［7］ Homeber M, Flscher I, Dlmeo F, et al. Cancerrelated fatigue:epidemiology,pathogenesis,diagnosis,and treatment［J］. Dtsch Arztebl Int, 2012, 109(9):161172. ［8］ Alfano CM, Imayama I, Neuhouser ML, et al. Fatigue,inflammation,and ω3 and ω6 fatty acid intake among breast cancer survivors［J］. J Clin Oncol, 2012, 30(20):12801287. ［9］ Moraska AR, Sood A, Dakhil SR, et al. Phase Ⅲ,randomized,doubleblind,placebocontrolled study of longacting methylphenidate for cancerrelated fatigue:North Central Cancer Treatment Group NCCTGN05C7 trial［J］. J Clin Oncol, 2010, 28(23):36733679. ［10］ Bower JE, Ganz PA, Irwin MR, et al. Inflammation and behavioral symptoms after breast cancer treatment:do fatigue,depression,and sleep disturbance share a common underlying mechanism?［J］. J Clin Oncol, 2011, 29(26):35173522. ［11］ Inagaki M, Isono M, Okuyama T, et al. Plasma interleukin6 and fatigue in terminally ill cancer patients［J］. J Pain Symptom Manage, 2008, 35(2):153161. ［12］ Berger AM. Update on the state of the science:sleepwake disturbances in adult patients with cancer［J］. Oncol Nurs Forum, 2009, 36(4):E165177. ［13］ Wang XS, Shi Q, Williams LA, et al. Inflammatory Cytokines are associated with the development of symptom burden in patients with nsclc undergoing concurrent chemoradiation therapy［J］. Brain Behav Immun, 2010, 24(6):968974. ［14］ Wang XS, Williams LA, Krishnan S, et al. Serum sTNFR1,IL6,and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy［J］. Brain Behav Immun, 2012, 26(5):699705. ［15］ Bower JE, Ganz PA, Tao ML, et al. Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer［J］. Clin Cancer Res, 2009, 15(1):55345540. ［16］ Barsevick A, Frost M, Zwinderman A, et al. I′m so Tired:Biological and Genetic Mechanisms of Cancerrelated Fatigue［J］. Qual Life Res, 2010, 19(10):14191427. ［17］ Bower JE, Ganz PA, Irwin MR, et al. Fatigue and gene expression in human leukocytes:Increased NFκB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue［J］. Brain Behav Immun, 2011, 25(1):147150. ［18］ ColladoHidalgo A, Bower JE, Ganz PA, et al. Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings［J］. Brain Behav Immun, 2008, 22(8):11971200. ［19］ Miaskowski C, Dodd M, Lee K, et al. Preliminary evidence of an association between a functional interleukin6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers［J］. J Pain Symp Manage, 2010, 40 (4): 531544. ［20］ Jim HS, Park JY, PermuthWey J, et al. Genetic Predictors of Fatigue in Prostate Cancer Patients Treated with Androgen Deprivation Therapy: Preliminary Findings［J］. Brain Behav Immun, 2012, 26(7):10301036.

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