周期素依赖性激酶10与肿瘤发生

doi:10.3760/cma.j.issn.1673-422X.2014.11.004

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (11): 811-812.doi: 10.3760/cma.j.issn.1673-422X.2014.11.004

周期素依赖性激酶10与肿瘤发生

漯河医学高等专科学校药学系

出版日期:2014-12-03 发布日期:2015-01-20
通讯作者: 游颜杰，Email: youyanjie@163.com
基金资助:
河南省科技攻关计划（142102310464）

Cyclin-dependent kinase 10 and tumorigenesis

Department of Pharmacy, Luohe Medical College, Luohe 462002, China

Online:2014-12-03 Published:2015-01-20
Contact: You Yanjie, Email: youyanjie@163.com

摘要/Abstract

摘要： 周期素依赖性激酶10（CDK10）通过与转录因子Ets2相互作用参与调控细胞周期，发挥抑癌基因的作用。研究表明CDK10表达下调与多种肿瘤形成密切相关，提示CDK10有希望成为针对恶性肿瘤的潜在分子诊断标志物和治疗靶点。

关键词: 基因, 肿瘤抑制, 肿瘤, 肿瘤标记, 生物学, 诊断

Abstract: Cyclindependent kinase 10 (CDK10) function as a tumor suppressor gene through regulating cell cycle interacting with transcription factor Ets2. Studies demonstrate that the downregulation of CDK10 expression occurs in multiple cancer types, indicating a potential application of CDK10 as a molecular diagnostic marker as well as therapeutic target.

Key words: Genes, tumor suppressor, Neoplasms, Tumor markers, biological, Diagnosis

游颜杰, 李文梅, 刘佳佳, 苑艺. 周期素依赖性激酶10与肿瘤发生[J]. 国际肿瘤学杂志, 2014, 41(11): 811-812.

YOU Yan-Jie, LI Wen-Mei, LIU Jia-Jia, YUAN Yi. Cyclin-dependent kinase 10 and tumorigenesis[J]. Journal of International Oncology, 2014, 41(11): 811-812.

参考文献

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周期素依赖性激酶10与肿瘤发生

Cyclin-dependent kinase 10 and tumorigenesis

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