国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (10): 747-749.doi: １０．３７６０／ｃｍａ．ｊ．ｉｓｓｎ．１６７３４２２Ｘ．２０１４．１０．００９

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肿瘤放疗抵抗机制研究进展

刘珊,蒋永新,熊伟,付凤莲   

  1. ６５０１１８昆明医科大学第三附属医院教学管理科
  • 出版日期:2014-10-29 发布日期:2014-10-11
  • 通讯作者: 蒋永新，Ｅｍａｉｌ：ｊｉａｎｇｙｘ１４７＠１６３．ｃｏｍ E-mail:ｊｉａｎｇｙｘ１４７＠１６３．ｃｏｍ

Research progress of mechanism of tumor radioresistance

 LIU  Shan, JIANG  Yong-Xin, XIONG  Wei, FU  Feng-Lian   

  1. Department of Teaching Management, Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China
  • Online:2014-10-29 Published:2014-10-11
  • Contact: ＪｉａｎｇＹｏｎｇｘｉｎ E-mail:ｊｉａｎｇｙｘ１４７＠１６３．ｃｏｍ

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2118

被引次数

4

摘要： 放疗抵抗是导致临床放疗失败及影响患者病情进展的主要原因。放疗抵抗的发生与细 胞周期阻滞、相关基因改变、肿瘤微环境变化、自噬性调节及肿瘤干细胞的存在等多种因素相关。研究 放疗抵抗机制，并寻找有效应对措施以减少放疗抵抗是提高放疗疗效的关键，同时也将为肿瘤放疗敏感 性的预测提供可能。

关键词: 肿瘤, 治疗, 放射疗法

Abstract: Tumor radioresistance is the leading cause of clinical radiotherapy failure and disease progression. Researches show that the occurrence of radioresistance is related to the cell cycle arrest, relevant gene change, tumor microenvironment change, autophagy, tumor stem cells and other factors. Studying the mechanism of radioresistance and looking for an effective method to avoid it is the key to improve the effect of radiotherapy, which can provide the probability of the prognosis of radiosensitivity.

Key words: Neoplasms, Therapy, Radiotherapy