国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (10): 737-740.doi: 10.3760/cma.j.issn.1673422X.2014.10.006

• 综述 • 上一篇    下一篇

盐霉素的抗肿瘤机制

卢颖,马威,毛俊,李连宏   

  1. 116044大连医科大学辽宁省肿瘤干细胞研究重点实
    验室,病理学与法医学教研室
  • 出版日期:2014-10-29 发布日期:2014-10-11
  • 通讯作者: 李连宏,Email:lilianhong917@126.com E-mail:lilianhong917@126.com
  • 基金资助:

    国家自然科学基金(81272430)

Anticancer mechanism of salinomycin

 LU  Ying, MA  Wei, MAO  Jun, LI  Lian-Hong   

  1.  Pathology and Forensic Medicine Teaching and Research Section, Key Laboratory of Cancer Stem Cell Research of Liaoning Province, Dalian Medical University, Dalian 116044, China
  • Online:2014-10-29 Published:2014-10-11
  • Contact: LiLianhong E-mail:lilianhong917@126.com

摘要: 盐霉素是一种广谱抗肿瘤药物,能抑制肿瘤生长并能特异性地杀伤肿瘤干细胞,其抗肿 瘤作用的潜能引起了国内外广泛关注。盐霉素主要通过诱导肿瘤细胞的凋亡,抑制肿瘤细胞的增殖和 转移,降低肿瘤细胞的耐药性等来实现其抗肿瘤作用。

关键词: 肿瘤, 肿瘤干细胞, 盐霉素

Abstract: Salinomycin is a chemotherapeutic drug commonly used to inhibit the growth of tumor and specifically kill the cancer stem cells (CSC). The anticancer effect of salinomycin has attracted extensive attention at home and abroad, whihc is realized by inducing cancer cell apoptosis, suppressing cancer cell proliferation and invasion and reducing drug resistance.

Key words: Neoplasms, Neoplastic stem cells, Salinomycin