国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 652-655.

• 综述 • 上一篇    下一篇

低氧诱导因子-1及转化生长因子-β与肿瘤

高超, 冯向营   

  1. 116021大连大学附属新华医院神经内科

  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 冯向营，E-mail: daiyue315@126. com E-mail:daiyue315@126. com

Hypoxia-inducible factor-1 and transforming growth factor-β in tumor

GAO  Chao, FENG  Xiang-Ying   

  1. Department of Neurology, Xinhua Hospital, Dalian University, Dalian 116021, China

  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: FENG Xiang-ying, E-mail: daiyue315@126.com E-mail:daiyue315@126. com

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摘要： 低氧诱导因子-1（HIF-1）是最重要的低氧信号传递因子，普遍存在于大多数实体肿瘤。体内外实验证明HIF-1通过调节转化生长因子β（TGF-β）的表达水平，协同TGF-β发挥促肿瘤作用，进而影响肿瘤的发展及预后。

关键词: 低氧诱导因子-1, 转化生长因子-β, 肿瘤, 血管内皮生长因子

Abstract: Hypoxia-inducible factor-1 (HIF-1) is one of the most important hypoxia signal transmission factor, and it has been observed in many human tumors. HIF-1 could play a role of promoting tumor by regulating the expression level of transforming growth factor-β in vivo and in vitro, and then affecting the development and prognosis of tumor.

Key words: Hypoxia-inducible factor-1, Transforming growth factor-β, Neoplasms, Vascular endothelial growth factors