国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 655-658.

• 综述 • 上一篇    下一篇

抗肿瘤药物对髓系来源抑制性细胞的影响

王甜, 梁晓华   

  1. 200040上海，复旦大学附属华山医院肿瘤科
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 梁晓华，E-mail: liangxiaohua@csco.org.cn E-mail:liangxiaohua@csco.org.cn
  • 基金资助:

    国家自然科学基金（81000910、81101551）

Effects of anti-tumor drugs to myeloid-derived suppressor cells

WANG  Tian, LIANG  Xiao-Hua   

  1. Department of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, China

  • Online:2013-09-08 Published:2013-09-16
  • Contact: LIANG Xiao-hua，E-mail: liangxiaohua@csco.org.cn E-mail:liangxiaohua@csco.org.cn

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被引次数

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摘要： 髓系来源抑制性细胞（MDSC）在肿瘤发生发展过程中发挥重要的免疫抑制作用，许多肿瘤进展均伴有MDSC的异常聚集，许多因素均可影响MDSC的聚集和功能，在肿瘤治疗过程中如何有效降低MDSC的免疫抑制作用成为学者们关注的焦点。近来研究表明，抗肿瘤药物可以影响MDSC的许多生物学行为。

关键词: 髓系细胞, 抗肿瘤药, 免疫抑制剂, 髓系抑制性细胞

Abstract: Myeloid-derived suppressor cells (MDSCs) play an important immunosuppressive role during the tumor development process. And the progression of many tumors are always accompanied with abnormal accumulation of MDSCs. Moreover, both the accumulation and functions of MDSCs could be affected by complicated factors. Therefore, how to effectively reduce the immunosuppressive effects of MDSCs in oncotherapy has become the focus of scholars. Recent studies show that anti-tumor drugs can affect many biological behaviors of MDSCs.

Key words: Myeloid cells, Antineoplastic agents, Immunosuppressive agents, Myeloied devrived suppressor cells