组蛋白脱乙酰基酶及其抑制剂对肿瘤的作用

doi:10.3760/cma.j.issn.1673-422X.2019.04.009

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (4): 235-238.doi: 10.3760/cma.j.issn.1673-422X.2019.04.009

组蛋白脱乙酰基酶及其抑制剂对肿瘤的作用

梁敬^1,3,韩莎²,姚静³,孔庆胜²

¹曲阜师范大学生命科学学院，济宁 273165； ²山东省出生缺陷研究与转化协同创新中心，济宁 272067；³济宁医学院基础医学院，济宁 272067

收稿日期:2019-01-10 修回日期:2019-02-28 出版日期:2019-04-08 发布日期:2019-05-29
通讯作者: 孔庆胜，Email: jnyxykqs@163.com E-mail:jnyxykqs@163.com
基金资助:
国家自然科学基金（81603143）；山东省自然科学基金（ZR2013CM031）

Effect of histone deacetylase and its inhibitor on tumor

Liang Jing^1,3, Han Sha², Yao Jing³, Kong Qingsheng²

¹Faculty of Life Sciences, Qufu Normal University, Jining 273165, China; ²Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining 272067, China; ³College of Basic Medical, Jining Medical University, Jining 272067, China

Received:2019-01-10 Revised:2019-02-28 Online:2019-04-08 Published:2019-05-29
Contact: Kong Qingsheng, Email: jnyxykqs@163.com E-mail:jnyxykqs@163.com
Supported by:
National Natural Science Foundation of China (81603143); Natural Science Foundation of Shandong Province of China (ZR2013CM031)

摘要/Abstract

摘要： 肿瘤的发生和进展是遗传和表观遗传共同作用的结果。组蛋白脱乙酰化修饰作为重要的表观遗传修饰的一种，对肿瘤的发生与发展有不可忽视的作用。组蛋白脱乙酰基酶在正常组织及细胞中的异常表达，会促进肿瘤的发展，并与肿瘤细胞的增殖和凋亡、血管生成、转移及耐药等方面相关，成为肿瘤治疗的新靶点。组蛋白脱乙酰基酶抑制剂作为抗肿瘤药物显示出良好的应用前景。

关键词: 组蛋白脱乙酰基酶类, 肿瘤转移, 抗肿瘤药, 组蛋白脱乙酰基酶抑制剂

Abstract: The occurrence and progress of tumor is the result of the interaction of heredity and epigenetics. Histone deacetylation modification, as an important epigenetic modification, plays an important role in tumorigenesis and development. The abnormal expression of histone deacetylase in normal tissues and cells promotes the development of tumor and is related to the proliferation and apoptosis, angiogenesis, metastasis and drug resistance of tumor cells, and becomes a new target of tumor therapy. Histone deacetylase inhibitors as antitumor drugs have a good prospect of application.

Key words: Histone deacetylases, Neoplasm metastasis, Antineoplastic agents, Histone deacetylase inhibitors

梁敬1,3,韩莎2,姚静3,孔庆胜2. 组蛋白脱乙酰基酶及其抑制剂对肿瘤的作用[J]. 国际肿瘤学杂志, 2019, 46(4): 235-238.

Liang Jing1,3, Han Sha2, Yao Jing3, Kong Qingsheng2. Effect of histone deacetylase and its inhibitor on tumor[J]. Journal of International Oncology, 2019, 46(4): 235-238.

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组蛋白脱乙酰基酶及其抑制剂对肿瘤的作用

Effect of histone deacetylase and its inhibitor on tumor

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