非精神活性大麻二酚抗肿瘤研究新进展

doi:10.3760/cma.j.cn371439-20200615-00089

摘要/Abstract

摘要：

大麻二酚是汉麻中最丰富的植物大麻素之一,不具有精神活性,其在体内具有多样化的药理作用。近年来研究发现大麻二酚具有良好的抗肿瘤活性,作用受体分布及激活机制的多样性使其可通过影响肿瘤细胞增殖、诱导细胞凋亡、抑制细胞侵袭和转移、抗血管生成和调节免疫反应等多个途径抑制肿瘤的发生发展。进一步了解大麻二酚在肿瘤中的作用机制有望为开发新型抗肿瘤药物提供新的思路。

关键词: 肿瘤, 大麻二酚, 抗肿瘤药

Abstract:

Cannabidiol is one of the most abundant phytocannabinoids in hemp, which has no psychoactive properties and a variety of pharmacological actions in vivo. Several recent studies indicate that cannabidiol possesses antitumor activity, the diversity of its acting receptor distribution and activation mechanism makes it possible to inhibit tumorigenesis in multiple ways via affecting tumor cell proliferation, inducing apoptosis, inhibiting cell invasion and metastasis, anti-angiogenesis and regulating immune response. Further understanding of the mechanism of cannabidiol in tumors may provide new ideas for the development of new antitumor agents.

Key words: Neoplasms, Cannabidiol, Antineoplastic agents

王爽, 汤云云, 岳琦. 非精神活性大麻二酚抗肿瘤研究新进展[J]. 国际肿瘤学杂志, 2020, 47(10): 619-623.

Wang Shuang, Tang Yunyun, Yue Qi. New progress in antitumor research of non-psychoactive cannabidiol[J]. Journal of International Oncology, 2020, 47(10): 619-623.

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