国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 520-522.

• 综述 • 上一篇    下一篇

循环肿瘤细胞与肺癌

龚磊, 范云   

  1. 310022  浙江省肿瘤医院肿瘤内科
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 范云, E-mail:fanyun@csco.org.cn E-mail:fanyun@csco.org.cn

Circulating tumor cells and lung cancer

GONG  Lei, FAN  Yun   

  1. Department of Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Online:2013-07-08 Published:2013-07-08
  • Contact: FAN Yun E-mail:fanyun@csco.org.cn

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摘要： 循环肿瘤细胞（CTC）与肿瘤转移有明显的相关性，CTC检测有助于指导肿瘤治疗，为判断预后、预测疗效提供可靠依据。CTC与非小细胞肺癌的分期及远处转移相关。CTC数量变化与非小细胞肺癌患者化放疗疗效及预后有关。小细胞肺癌中CTC检出率和数量均明显高于其他肿瘤，与其分期及化疗疗效有关。CTC有望用于指导肺癌个体化治疗。初步研究结果提示可用CTC来动态了解肺癌患者分子靶向药物治疗过程中耐药肿瘤细胞的出现。

关键词: 肺肿瘤, 肿瘤转移, 靶向治疗

Abstract: Circulating tumor cells (CTCs) play an important role in tumor metastasis. Detections of CTCs are contribute to tumor treatment, which can provide reliable basis for predicting the prognosis and efficacy. CTCs are related to the staging and distant metastasis of non-small cell lung cancer (NSCLC). The number changes of CTCs are associated with the chemotherapy and radiotherapy effects and prognosis in NSCLC. Almost the same phenomena have been discovered in small cell lung cancer. In the future, CTCs may be used to monitor the occurrence of drug resistant tumor cells and help individual therapy for lung cancer.

Key words: Lung neoplasms, Neoplasm metastasis, Targeted therapy