国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 483-485.

• 综述 •    下一篇

肥大细胞与肿瘤血管生成的研究进展 

曹莉,李维,邓凡   

  1. 510515 广东广州南方医科大学细胞生物学教研室
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 邓凡, E-mail:fandeng@smu.edu.cn E-mail:fandeng@smu.edu.cn
  • 基金资助:

    国家自然科学基金（30973014，81272852）

Mast cells and tumor angiogenesis

CAO  Li, LI  Wei, DENG  Fan-   

  1. Department of Cell Biology, Southern Medical University, Guangzhou 510515, China
  • Online:2013-07-08 Published:2013-07-08
  • Contact: DENG Fan E-mail:fandeng@smu.edu.cn

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摘要： 肥大细胞（MC）是起源于骨髓，定居于组织的重要功能的免疫细胞。肿瘤可以通过干细胞因子（SCF）及其在肥大细胞上的受体c-kit来介导对MC的募集。新生血管为肿瘤提供充足的营养与氧气，为肿瘤生长所必需。MC在肿瘤部位的数量和分布与肿瘤的生长、血管新生密切相关。MC可以通过释放血管生成因子介导血管新生，促进肿瘤的进展。

关键词: 肥大细胞, 肿瘤, 新生血管化, 病理性

Abstract:  Mast cells (MCs) are bone marrow-derived and tissue-homing immune cells which have important functions. Recruitment and activation in tumors are demonstrated to be mainly mediated by tumor-derived stem cell fact MCs in tumors are closely related to the growth of tumors and angiogenesis. MCs can or (SCF) and its receptor c-kit on MCs. Neovascularization is necessary for the tumor growth by providing plenty of nutrients and oxygen. The numbers and distributions of mediate angiogenesis by releasing a series of angiogenesis factors, so as to promote the progress of tumors.

Key words: Mast cells, Neoplasms, Neovascularization, pathologic