国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 419-421.

• 综述 • 上一篇    下一篇

MicroRNA-203与肿瘤

齐秋锋, 刘永萍   

  1. 213001 常州市肿瘤医院肿瘤内科实验室
  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 刘永萍，E-mail：liuyongping026@yahoo.com.cn E-mail:liuyongping026@yahoo.com.cn
  • 基金资助:

    江苏省科教兴卫工程(LJ201157)

MicroRNA-203 and cancer

QI  Qiu-Feng, LIU  Yong-Ping   

  1. Department of Medicine  Oncology Laboratory, Changzhou Tumor Hospital, Changzhou 213002, China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: Liu Yong-ping E-mail:liuyongping026@yahoo.com.cn

PDF

1537

被引次数

6

摘要： 微RNA（miRNA）-203具有细胞干性抑制潜能，可通过抑制细胞干性相关转录因子的表达来调节细胞上皮样分化。研究表明miRNA-203在多种肿瘤组织中表达异常，包括膀胱癌、乳腺癌、结肠癌和胰腺癌等。miRNA-203通过调节细胞增殖、分化和凋亡在肿瘤的发生、发展中发挥重要作用。

关键词: 肿瘤, MicroRNA-203, 靶基因

Abstract: MicroRNA(miRNA)-203 is a stemness-inhibiting miRNA that adjusts the epithelioid cell differentiation by restricting the expression of stemness-related transcription factor. Its abnormal expression has been detected in several types of human cancers, including bladder cancer, breast cancer, colon cancer and pancreatic cancer. MiRNA-203 plays a critical role in the tumor genesis and development by regulating cell proliferation, differentiation and apoptosis.

Key words: Neoplasms, MicroRNA-203, Target gene