国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (4): 249-251.

• 综述 • 上一篇    下一篇

MCM2与肿瘤

汪志辉, 生秀杰   

  1. 510150 广州医学院第三附属医院妇科
  • 出版日期:2013-04-08 发布日期:2013-03-27

The  MCM2 and cancers

WANG  Zhi-Hui, SHENG  Xiu-Jie   

  1. Gynecology Department, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China

  • Online:2013-04-08 Published:2013-03-27

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被引次数

1

摘要： 微小染色体维持蛋白（MCM）是真核生物DNA复制的主要调控因子之一，在DNA复制的起始和延长过程中发挥着重要的作用，其家族成员中的MCM2在静止期细胞中不表达，而在增殖、转化细胞中过度表达，能准确反映细胞的增殖活性，是细胞进入增殖期敏感而特异的指标，被视为特异性增殖的癌前标志物。MCM2的过度表达与肿瘤的发生发展密切相关，有可能作为多种肿瘤早期筛查和评估预后的较好指标而应用于临床。

关键词: 肿瘤, 肿瘤标记, 生物学, 微小染色体维持蛋白

Abstract: Minichromosome maintenance proteins（MCMs） are the primary control factors for eukaryotes DNA replication. MCMs play important roles in the starting place and the extending process of DNA replication.MCM2, one member of MCMs, expresses little in stationary phase while highly in proliferative and transformational phase. MCM2 can accurately reflect the cell proliferation activity and is considered as a specific maker for carcinoma and precancerous lesions.The overexpression of MCM2 is closely correlated with the genesis and development of tuomors, and it maybe a good maker for early screening and prognosis assessment in many cancers and used in clinical.

Key words: Neoplasms, Tumor markers, biological, Minichromosome maintenance protein-2