国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (4): 246-249.

• 综述 • 上一篇    下一篇

Mel-18基因与肿瘤

许学宗，曹京燕，于雁   

  1. 150081哈尔滨医科大学附属肿瘤医院内六科
  • 出版日期:2013-04-08 发布日期:2013-03-27
  • 通讯作者: 于雁，E-mail：gpyuyan@163.com E-mail:gpyuyan@163.com
  • 基金资助:

    国家自然科学基金（30973417、81108751）；中国博士后资助项目（2012M511514）

Mel-18 gene and neoplasms

XU Xue-zong,CAO Jing-Yan, YU Yan   

  1. Department VI of Internal Medicine, Tumor Hospital Affiliated to Harbin Medical University, Harbin 150081, China

  • Online:2013-04-08 Published:2013-03-27
  • Contact: YU Yan E-mail:gpyuyan@163.com

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被引次数

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摘要： 黑色素瘤核蛋白-18（Mel-18）基因是多梳基因（PcG）家族核心成员之一，在胚胎形成、细胞生长和增殖、干细胞自我更新的调节中发挥重要作用。Mel-18基因表达异常与人类肿瘤的发生、发展过程有关。作为肿瘤抑制基因，Mel-18基因通过对B淋巴瘤Mo-MLV插入区域1（Bmi-1）和髓细胞癌基因（c-myc）的转录抑制而抑制肿瘤增长。Mel-18表达在许多肿瘤细胞的转录水平和翻译水平减少，其中包括乳腺癌、前列腺癌和胃癌等肿瘤，有望成为一种新的肿瘤预后标志物。

关键词: 肿瘤, 基因, 肿瘤抑制, Mel-18

Abstract: Mel-18 gene is one of the core members of the PcG (polycomb group,) family,which plays an important role in embryogenesis, cell growth and proliferation and self-renewal of stem cells. Mel-18 gene expressing abnormally has been related to human tumorigenesis, development process. Mel-18 serves as a tumor suppressor gene and inhibits tumor growth through transcriptional repression of Bmi-1 and c-myc. Mel-18 expression is decreased at transcriptional and translational levels in most human cancers including breast cancer, prostate cancer, and gastric cancer and other tumors. Mel-18 is expected to become a prognostic marker for human cancers.

Key words: Neoplasms, Genes, tumor suppressor, Mel-18