国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (4): 243-246.

• 综述 •    下一篇

MICA基因与肿瘤

王云炎, 徐宗源, 孟峻嵩   

  1. 223300 南京医科大学附属淮安第一医院泌尿外科
  • 出版日期:2013-04-08 发布日期:2013-03-27
  • 通讯作者: 王云炎，E-mail: wangyunyan2000@hotmail.com E-mail:wangyunyan2000@hotmail.com
  • 基金资助:

    南京医科大学校基金面上项目（2011NJMU123）

MICA gene and tumors

WANG  Yun-Yan, XU  Zong-Yuan, MENG  Jun-Song   

  1. Department of Urology Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China
  • Online:2013-04-08 Published:2013-03-27
  • Contact: WANG Yun-yan E-mail:wangyunyan2000@hotmail.com

PDF

1551

摘要： 主要组织相容性复合物Ⅰ链相关基因A(MICA)位于人第6号染色体的主要组织相容性复合物Ⅰ（MHC-Ⅰ）类区域中，该基因包含6个外显子，编码的蛋白分子结构域与经典的Ⅰ类分子α链相似，包括3个胞外结构域：α1、α2和α3，以及跨膜区和胞质区，但不含β2微球蛋白。MICA 表达于内皮细胞、上皮细胞以及大多数上皮性肿瘤细胞表面，参与多种肿瘤细胞的分化、增殖和浸润过程。可溶性MICA（sMICA）可以作为部分恶性肿瘤的预后预测因子。MICA基因在多种恶性肿瘤的发病机制中具有重要作用，可能为恶性肿瘤防治带来新的思路。

关键词: 肿瘤, 肿瘤逃逸, MHC-Ⅰ链相关基因A

Abstract: Major histocompatibility complex class Ⅰchain related gene A(MICA) is located within the MHC class Ⅰ region of chromosome 6, including six exons. The MICA locus encodes membrane-bound polypeptides, similar with the classic class Ⅰ molecules, including three extracellular domains (α1, α2, and α3), a transmembrane domain, and a cytoplasmic tail, but is not associated with β2-microglobulin. MICA gene are expressed on endothelial cells, epithelial cells as well as most epithelial tumor cell surface, and are involved in the process of cell differentiation, proliferation and infiltration in a variety of tumor cells. Soluble MICA(sMICA) can be used as the prognosis predicting factor for some tumors. MICA gene plays an important role in the pathogenesis of a variety of malignant tumors, which might bring new ideas in prevention and treatment for malignant tumors.

Key words: Neoplasms, Tumor escape, Major histocompatibility complex class Ⅰ chain related gene A