国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 177-181.

• 综述 • 上一篇    下一篇

上皮细胞间质转化与肿瘤干细胞

强素凤, 黄勇   

  1. 200030 上海交通大学医学院附属国际和平妇幼保健院妇科

  • 出版日期:2013-03-08 发布日期:2013-02-25
  • 通讯作者: 黄勇，Email: E-mail:drhuangyong@yahoo.com.cn

Epithelial-mesenchymal transition and cancer stem cells

QIANG  Su-Feng, HUANG  Yong   

  1. Department of Gynaecology, International Peace Maternity and Child Health Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2013-03-08 Published:2013-02-25
  • Contact: HUANG Yong, E-mail: drhuangyong@yahoo.com.cn E-mail:drhuangyong@yahoo.com.cn

PDF

2042

被引次数

7

摘要： 上皮间质转化(EMT)不仅赋予细胞迁移和侵袭特征，还可使肿瘤细胞获得自我更新能力而具有干细胞的特性，从而促进肿瘤干细胞(CSC)的产生。EMT与CSC有相通的分子机制及微环境，这对侵袭性肿瘤的诊治具有重大临床意义。另外，微小RNA（miR）-200可调控EMT及CSC，参与肿瘤的侵袭和转移,促进肿瘤靶向治疗的研究。

关键词: 肿瘤, 肿瘤干细胞, 微RNAs, 上皮间质转化

Abstract: Epithelial-mesenchymal transition (EMT) not only can endow cells migration and invasion characteristics, but also can make tumor cells obtain self-renewal ability and have the characteristics of stem cells, which might result in cancer stem cell (CSC). There are the same molecular mechanism and microenvironment between EMT and CSC, which have great clinic significances for the diagnosis and treatment of the aggressive cancers. Moreover, many studies show that miR-200 could regulate EMT and CSC, participate in the tumor invasion and metastasi, and promote the research of targeted cancer therapy.

Key words:  Neoplasms, Neoplastic stem cells, MicroRNAs, Epithelial-mesenchymal transitions