国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 742-744.

• 综述 • 上一篇    下一篇

CXCR7在肿瘤侵袭和转移中的研究

高超, 支宇, 冯向营   

  1. 116021 大连大学附属新华医院神经内一科
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 冯向营，E-mail: daiyue315@126.com E-mail:daiyue315@126.com

Chemokine receptor CXCR7 in tumor invasion and metastasis

GAO  Chao, ZHI  Yu, FENG  Xiang-Ying   

  1. First Department of Neurology, Affiliated Xinhua hospital of Dalian University, Dalian 116021, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: Corresponding author: FENG Xiang-ying, E-mail: daiyue315@126.com E-mail:daiyue315@126.com

PDF

1292

被引次数

2

摘要： 趋化因子在细胞的转化和黏附中发挥重要作用。现已证实CXCR7与趋化因子CXCL12和CXCL11有高亲和力，而且趋化因子受体CXCR7激活后，可通过调节细胞外基质(ECM)、上皮-间质转化(EMT)及其他信号转导通路等影响肿瘤的侵袭和转移。因此，深入研究趋化因子受体CXCR7与肿瘤侵袭和转移的分子机制有望为肿瘤治疗提供更有效的理论基础。

关键词: CXCR7, 肿瘤, 细胞外基质, 上皮-间质转化

Abstract: Chemokines are major regulators of cell transformation and adhesion. Recent study has demonstrated that CXCR7 can bind to CXCL11 and CXCL12 with high affinity, and the activated CXCR7 may influence tumor invasion and metastasis by regulating extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) and other signal transduction pathways. Therefore, in-depth study of  the molecular mechanisms between CXCR7 and tumor invasion and metastasis may provide a more effective theoretical basis for tumor treatment.

Key words: CXCR7, Neoplasms, Extracellular matrix, Epithelial-mesenchymal transition