国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (1): 18-21.

• 综述 • 上一篇    下一篇

CD44在肿瘤进展中的作用

李丹华, 张斌, 曹旭晨   

  1. 300060 天津医科大学附属肿瘤医院乳腺一科 乳腺癌防治教育部重点实验室 天津市肿瘤防治重点实验室

  • 出版日期:2013-01-08 发布日期:2013-01-15
  • 通讯作者: 曹旭晨,E-mail:cxc@medmail.com.cn E-mail:cxc@medmail.com.cn
  • 基金资助:

    国家自然科学基金(81001186)天津市自然科学基金(10JCYBJC14100,11JCZDJC28000)

Effects of CD44 in cancer progression

LI  Dan-Hua, ZHANG  Bin, CAO  Xu-Chen   

  1. First Department of Breast Oncology, Affiliated Cancer Hospital of Tianjin Medical University; Key Laboratory of Breast Cancer Prevention and Treatment of Ministry of Education; Key Laboratory of Cancer Prevention and Treatment of Tianjin, Tianjin 300060, China
  • Online:2013-01-08 Published:2013-01-15
  • Contact: Corresponding author: CAO Xu-chen, E-mail: cxc@medmail.com.cn E-mail:cxc@medmail.com.cn

摘要: CD44在生理过程及肿瘤中的作用一直是研究的热点,通过与不同配体结合,可激活一系列级联反应,不仅可以促进肿瘤形成和转移,还可以抑制肿瘤生长和进展。深入研究CD44及其在信号通路中的作用,可为肿瘤治疗提供新途径。

关键词: CD44, 肿瘤转移, 预后

Abstract: CD44 has been the subject of extensive research because of its role in cancer and many physiological processes. Through binding to different ligands, CD44 can initiate a series of cascade. CD44 not only can promote tumorigenic and tumor metastasis, but also can suppress tumor growth and progression. In-depth study of CD44 and its role in signal pathway may provide a new path for cancer treatment.

Key words: CD44, Neoplasm metastasis, Prognosis