国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 693-696.

• 综述 • 上一篇    下一篇

PIK3CA基因与结直肠癌发生发展的研究

蔡彦韬,杨逸,项建斌,陈宗祐   

  1. 200040上海，复旦大学附属华山医院普外科
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 通讯作者: 陈宗祐，E-mail: zongyouchen@hotmail.com E-mail:zongyouchen@hotmail.com

Role of PIK3CA gene in colorectal cancer genesis and development

 CAI  Yan-Tao, YANG  Yi, XIANG  Jian-Bin, CHEN  Zong-You   

  1. Department of General Surgery, Huashan Hospital, Shanghai 200040, China
  • Online:2012-09-22 Published:2012-09-24
  • Contact: CHEN Zong-you, E-mail: zongyouchen@hotmail.com E-mail:zongyouchen@hotmail.com

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摘要： PIK3CA基因编码蛋白激酶PI3K的p100α亚单位，参与PI3K的合成，通过下游PI3K/AKT通路发挥其生物学效应。多种肿瘤组织中可检测到PIK3CA基因突变，突变的PIK3CA异常激活PI3K-AKT信号通路，导致细胞周期异常、细胞黏附性下降、细胞凋亡下调及新生血管形成等，促进肿瘤发生发展。研究表明PIK3CA与结直肠癌的发生、发展、分化、转移及耐药密切相关，有望在结直肠癌的早期诊断、基因筛查、治疗方案制定、复发随访等方面提供一定的临床证据。

关键词: 结直肠肿瘤, PI3K信号通路

Abstract: The PIK3CA gene codes p100α, the catalytic  subunit of phosphatidylinositol 3-kinase (PI3K) and is involved in the initiating the PI3K/AKT pathway. PIK3CA plays its biological roles through.downstream PI3K pathway. PIK3CA gene mutants can be detected in many kinds of tumors. The mutant PIK3CA gene can abnormally activate PI3K pathway, leading to the abnormal cell cycle, decreased cell adhesion, down regulated apoptosis and neovascularization, and then promotes tumor genesis and development. Recent researches have found that mutant PIK3CA gene is closely correlated with the genesis, development, differentiation, metastasis and drug resistance of colorectal cancer. Research of PIK3CA in colorectal cancer may provide significant evidence for the early diagnosis, gene screen, therapeutic regimen making, recurrence and follow up.

Key words: Colorectal Neoplasms, PI3K pathway