国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 662-664.

• 综述 • 上一篇    下一篇

活化激酶C受体与肿瘤

李秀萍,肖明明,景士兵   

  1. 110016 沈阳，辽宁省人民医院病理科
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 通讯作者: 李秀萍,E-mail：lixiupingli@126.com E-mail:lixiupingli@126.com

Receptor for activated C kinase 1 and neoplasms

 LI  Xiu-Ping, XIAO  Ming-Ming, JING  Shi-Bing   

  1. Department of Pathology, Liaoning Provincial People′s Hospital,Shenyang 110016, China
  • Online:2012-09-22 Published:2012-09-24
  • Contact: LI Xiu-ping, E-mail: lixiupingli@126.com E-mail:lixiupingli@126.com

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摘要： 活化激酶C受体(RACK1)蛋白作为一种锚定蛋白，可以与细胞中多种信号分子结合，参与细胞内许多信号通路的传导。RACK1在肿瘤细胞信号转导分子网络中的作用受到了研究者的关注。大量研究揭示了肿瘤细胞中RACK1通过调节肿瘤血管形成和免疫逃逸，调节信号转导，并发挥重要的作用。

关键词: 肿瘤, 活化激酶C受体, 生物学标记

Abstract: As an anchoring protein, receptor for activated C kinase 1(RACK1) can combine together with many kinds of intracellular signaling molecules and participate in many signal conduction in cells. Researchers have paid close attention to the role of RACK1 in signal transduction molecule network of tumor cells. Abundant studies reveal that RACK1 can regulate signal transduction by regulating tumorigenesis and immune escape in tumor cells, and then play important roles.

Key words: Neoplasms, Receptor for activated C kinase 1, Biological markers