国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 658-661.

• 综述 • 上一篇    下一篇

尾型同源盒基因与肿瘤

尹宝慧,贾秀红   

  1. 256603 山东省滨州医学院附属医院儿科
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 通讯作者: 贾秀红，E-mail:jiaxiuhong001@163.com E-mail:jiaxiuhong001@163.com

 YIN  Bao-Hui, JIA  Xiu-Hong   

  1. Department of Pediatrics, the Affiliated Hospital of Binzhou Medical University, Binzhou 256603, China
  • Online:2012-09-22 Published:2012-09-24
  • Contact: JIA Xiu-hong, E-mail:jiaxiuhong001@163.com E-mail:jiaxiuhong001@163.com

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摘要： 尾型同源盒基因（CDX）家族主要包括CDX1、CDX2 、CDX4，是同源盒基因（HOX）ParaHOX家族中的一员，作为转录调节因子在胚胎发育造血系统形成、肠上皮组织发育等过程中起了重要的作用。CDX异常表达常与肿瘤发生密切相关。研究CDX与肿瘤发生的关系，对肿瘤诊断、治疗等有重要意义。

关键词: 基因, 同源盒, 肿瘤

Abstract: The caudal-type homeobox gene is a member of homeobox gene—Para-HOX family, including CDX1,CDX2 and CDX4. As a transcriptional factor, CDX plays an important role in embryo development, hematopoietic system formation, intestinal epithelium tissue development and so forth. The abnormal expression of CDX is usually closely related with tumorigenesis. Researching the relationship between CDX and tumors will contribute to tumor diagnosis and treatment.

Key words: Genes, homeobox, Neoplasms