国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (6): 415-417.

• 综述 • 上一篇    下一篇

肝再生磷酸酶-3及其抑制剂在肿瘤中的作用

王雯娟,何太平   

  1. 湛江， 广东医学院生物化学与分子生物学研究所
  • 出版日期:2012-06-08 发布日期:2012-06-25
  • 通讯作者: 何太平，E-mail：taipinghe@163.com E-mail:taipinghe@163.com
  • 基金资助:

    广东省自然科学基金资助项目（ S2011010004146 ）

Roles of the liver regeneration phosphatase-3 and its inhibitors in tumor

WANG Wen-juan, HE Tai-ping   

  1. Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China
  • Online:2012-06-08 Published:2012-06-25
  • Contact: HE Tai-ping, E-mail: taipinghe@163.com E-mail:taipinghe@163.com

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摘要： 肝再生磷酸酶-3（PRL-3）是新的小分子蛋白质酪氨酸磷酸酶，在肿瘤的发生发展中有重要作用。研究发现，PRL-3通过参与多种信号通路调控肿瘤进展。PRL-3在肿瘤组织中高表达能明显促进肿瘤转移，但在多数正常组织中不表达，因此有望成为肿瘤诊断的标志物及肿瘤治疗的新靶点。

关键词: 蛋白质酪氨酸磷酸酶类, 肿瘤, 信号传导, 酪氨酸磷酸化抑制剂

Abstract: Phosphatase of regenerating liver-3 (PRL-3) is a novel small molecule proteintyrosinephosphatase, which plays an important role in the  oncogenesis and deveopment of tumors. Studies show that PRL-3 regulates neoplasm progress through participating in multiple signal pathways. Its high expression can significantly promote neoplasm metastasis in cancer tissue. However, there is no expression of PRL-3 in most normal tissue. PRL-3 is expected to be a potential tumor maker of diagnosis and a new target for the therapy of cancer. 

Key words: Protein tyrosine phosphatases, Neoplasm, Signal transduction, Tyrphostins