国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 272-274.

• 综述 • 上一篇    下一篇

微环境与乳腺癌新辅助化疗

荣国华, 康骅   

  1. 100053北京，首都医科大学宣武医院普外科
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 康骅，E-mail：kanghua@xwh.ccmu.edu.cn E-mail:kanghua@xwh.ccmu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（81172517）

Tumor microenvironment and neoadjuvant chemotherapy in breast cancer

RONG  Guo-Hua, KANG  Hua   

  1. Department of General Surgery, Xuanwu Hospital,  Capital Medical University, Beijing 100053, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: KANG Hua, E-mail: kanghua@xwh.ccmu.edu.cn E-mail:kanghua@xwh.ccmu.edu.cn

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摘要： 肿瘤微环境对于肿瘤发生、发展的作用以及对于辅助化疗、新辅助化疗疗效的影响越来越受到重视。研究表明乳腺癌微环境尤其是肿瘤间质纤维母细胞（CAF）及其合成的基质细胞衍生因子-1（SDF-1）和胶原，可对新辅助化疗产生重要的影响。

关键词: 乳腺肿瘤, 化学疗法, 辅助, 趋化因子CXCL12, 微环境

Abstract:  Recently many studies have focused on the roles that tumor microenvironment plays in the occurrence and development of tumors, and the therapeutic effects of adjuvant chemotherapy and neoadjuvant chemotherapy. Recent researches show that tumor microenvironment has an obvious impact on the therapeutic effects of neoadjuvant chemotherapy, which mainly includes cancer-associated fibroblasts (CAF), stromal cell derived factor-1 (SDF-1) and collagens.

Key words: Breast neoplasms, Chemotherapy, adjuvant, Chemokine CXCL12, Microenvironment