国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 249-251.

• 综述 • 上一篇    下一篇

Ku蛋白与肿瘤放射敏感性

李田芊, 于书慧, 李国苗, 李文辉   

  1. 650118昆明医学院第三附属医院放疗科
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 李文辉，E-mail: wenhuili64@yahoo.com.cn E-mail:wenhuili64@yahoo.com.cn
  • 基金资助:

    云南省社会发展科技计划项目（2009ZC117M）;云南省卫生科技计划项目（2010NS089）

Ku proteins and tumor radiosensitivity

LI  Tian-Qian, YU  Shu-Hui, LI  Guo-Miao, LI  Wen-Hui   

  1. Department of Radiation Oncology, Third Affiliated Hospital ofKunming Medical University, Kunming 650118, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: LI Wen-hui, E-mail: wenhuili64@yahoo.com.cn E-mail:wenhuili64@yahoo.com.cn

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被引次数

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摘要： Ku是由Ku70和Ku80两个亚基组成的异质二聚体蛋白，它与DNA依赖蛋白激酶催化亚单位(DNA-PKcs)共同组成DNA依赖的蛋白激酶。射线杀伤肿瘤细胞主要通过破坏DNA双链，导致DNA损伤不能修复，从而引起细胞凋亡。Ku蛋白是DNA损伤修复中的关键因子，通过阻断Ku蛋白能够增加肿瘤细胞的放射敏感性。

关键词: 肿瘤, 辐射耐受性, Ku蛋白

Abstract: Ku is a heterodimeric protein which is composed of Ku70 and Ku80. DNA dependent protein kinase is composed of Ku and DNA dependent protein kinase catalytic subunit (DNA-PKcs). DNA double strands break is the main method that radiation kill tumor cell, which will restraint DNA repair, and induce cell apoptosis. Ku protein is the key point in the repair of DNA. Blocking Ku protein will increase the radiosensitivity of tumor cell.

Key words: Neoplasms, Radiation tolerance, Ku proteins