国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 246-248.

• 综述 • 上一篇    下一篇

赖氨酰氧化酶样蛋白2与肿瘤的相关性及作用机制

武奋萍, 杨志雄   

  1. 524001 湛江，广东医学院附属医院肿瘤中心一区
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 杨志雄，E-mail：yangzhixiong068@126.com E-mail:yangzhixiong068@126.com

Correlation between lysyl oxidase-like protein 2 and neoplasms and its mechanism

WU  Fen-Ping, YANG  Zhi-Xiong   

  1. Departerment of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: YANG Zhi-xiong, E-mail: yangzhixiong068@126.com E-mail:yangzhixiong068@126.com

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摘要： 赖氨酰氧化酶样蛋白2（LOXL2）是赖氨酰氧化酶（LOX）家族成员之一。目前，大多数学者认为LOXL2是一种促进转移基因，也有一些认为是肿瘤抑制基因。研究发现LOXL2与多种基因联合协同作用，促进肿瘤侵袭、转移，且与不良预后相关，相关研究为判断肿瘤的转移和预后及寻找肿瘤治疗的新靶点提供了新思路。

关键词: 蛋白赖氨酸6-氧化酶, 肿瘤, 赖氨酰氧化酶样蛋白2

Abstract: Lysyl oxidase-like protein 2 (LOXL2) is one of the lysyl oxidases (LOX) families. At present, most of scholars consider that LOXL2 is a neoplasm metastasis gene, whereas some others believe that LOXL2 is a neoplasm suppressor gene. Studies found that LOXL2 gene combined with other oncogenes promotes neoplasm invasion, metastasis and indicates a poor prognosis. Related researches provide new ideas for judging tumor metastasis and prognosis and looking for new targets for cancer therapy.

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