国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (3): 169-171.

• 综述 • 上一篇    下一篇

氨肽酶N及其抑制剂与肿瘤

裴可灵,张厚莉,崔淑香   

  1. 250062 山东省医学科学院药物研究所山东省罕少见病重点实验室
  • 出版日期:2012-03-08 发布日期:2012-02-24
  • 基金资助:

    国家自然科学基金资助项目（81072665）

Aminopeptidase N and its inhibitors and carcinoma

PEI  Ke-Ling, ZHANG  Hou-Li, CUI  Shu-Xiang   

  1. Institute of Materia Medica, Shandong Academy of Medical Sciences, Key Laboratory for Rare Disease of Shandong Province, Jinan 250062, China
  • Online:2012-03-08 Published:2012-02-24

PDF

2082

被引次数

11

摘要： 氨肽酶N是一种锌离子依赖性的外肽酶，在多种肿瘤细胞表面高表达，可降解细胞外基质，促进血管生成，从而促进肿瘤侵袭转移。氨肽酶N抑制剂可抑制肿瘤侵袭转移，诱导肿瘤细胞凋亡，已成为抗肿瘤治疗的一个有吸引力的靶点。

关键词: 抗原, CD13, 肿瘤侵润, 肿瘤转移

Abstract: Aminopeptidase N, a zinc-dependent exopeptidase, is highly expressed in many kinds of tumors, which involves in the degradation of extracellular matrix barriers and angiogenesis and promotes the invasion and metastasis of cancer cells. Aminopeptidase N inhibitors can induce apoptosis and inhibit the invasion and metastasis of tumor cells, which has become an attractive target for anti-tumor therapy.

Key words: color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Antigens, color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">CD13, color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Neoplasm invasiveness, Neoplasm metastasis