国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (2): 92-95.

• 综述 • 上一篇    下一篇

细胞微环境介导肿瘤P-糖蛋白的表达调控

黄帆, 李远, 彭明清   

  1. 402160 重庆永川区重庆医科大学附属永川医院中心实验室
  • 出版日期:2012-02-08 发布日期:2012-01-18
  • 通讯作者: 李远，E-mail:liyuan_1985999@163.com E-mail:liyuan_1985999@163.com
  • 基金资助:

    重庆医科大学附属永川医院院级课题（YJQN 2011027）； 重庆永川区2011年科技支撑“健康永川”专项基金（YCSTC 2011BF5001）

Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer

HUANG  Fan, LI  Yuan, PENG  Ming-Qing   

  1. Central Laboratory, Yongchuan Hospital, Chongqing Medical University,Chongqing 402160, China
  • Online:2012-02-08 Published:2012-01-18
  • Contact: Corresponding author: LI Yuan, E-mail: liyuan_1985999@163.com E-mail:liyuan_1985999@163.com

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摘要： P-糖蛋白（P-gp）表达调控与肿瘤多药耐药的发生发展密切相关。肿瘤细胞面临自身微环境内源性损伤及外源性刺激伤害，这些不利的细胞微环境触发细胞应激反应，并通过激活系列信号传导通路调控P-糖蛋白的表达。研究肿瘤细胞内源性微环境与外源性刺激损伤对P-糖蛋白的表达调控将对探寻肿瘤细胞多药耐药获得具有重要意义。

关键词: 肿瘤, P糖蛋白, 抗药性, 信号传导

Abstract: Expression and regulation of the P-glycoprotein (P-gp) is associated with the development of multidrug resistance in cancer. Cancer cells are exposed in endogenous damages from its own micro-environments and inflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would have important significance for exploring the multidrug resistance of cancer cell.

Key words: font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">Neoplasms, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">P-glycoprotein,  Drug resistance, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">Signal transduction