国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (12): 935-938.

• 综述 • 上一篇    下一篇

微卫星不稳定性在结直肠癌中的意义

支文雪, 石素胜   

  1. 100021 北京协和医学院中国医学科学院肿瘤医院病理科
  • 出版日期:2012-12-08 发布日期:2012-11-15
  • 通讯作者: 石素胜，E-mail: shishusheng@sina.com.cn E-mail:shishusheng@sina.com.cn

Significance of microsatellite instability in colorectal cancer

ZHI  Wen-Xue, SHI  Su-Sheng   

  1. Department of Pathology, Cancer Hospital （Institute）,Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, China
  • Online:2012-12-08 Published:2012-11-15
  • Contact: Corresponding author：SHI Su-sheng, E-mail: shishusheng@sina.com.cn E-mail:shishusheng@sina.com.cn

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摘要： 微卫星不稳定性（MSI）是结直肠癌发生发展的重要分子机制，对结直肠癌具有重要临床意义。MSI是林奇综合征的诊断标志物。同时由于MSI阳性的结直肠癌比阴性者表现出更好的预后，且对5-氟尿嘧啶类化疗药物不敏感，MSI同样成为结直肠癌的预后和预测化疗疗效的标志物。

关键词: 微卫星不稳定性, 结直肠肿瘤, 预后, 药物疗法

Abstract: Microsatellite instability (MSI) is an important molecular mechanism in colorectal cancer’s initiation and progression, which has significant clinical significance. MSI is a diagnostic biomarker for Lynch synchrome. Moreover, the clinical implication of MSI testing extends to the role of prognostic marker and predictive maker, due to the better outcome of patients with MSI positive colorectal cancer and a general lack of response to chemotherapy employing 5-fluorouracil.

Key words: Microsatellite instability, Colorectal neoplasms, Prognosis, Drug therapy