国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 723-725.

• 综述 •    下一篇

细胞荷载溶瘤病毒

徐尊佑, 毛立军, 陈家存   

  1. 徐州医学院附属医院泌尿科（徐尊佑 、陈家存）；徐州医学院肿瘤生物治疗实验室（毛立军）
  • 出版日期:2011-10-08 发布日期:2011-09-27
  • 通讯作者: 毛立军，mljmlj05@126.com E-mail:mljmlj05@126.com
  • 基金资助:

    国家自然科学基金资助项目（3070099）；江苏省自然科学基金资助项目（BK2008122）

Cell-based delivery of oncolytic viruses

XU  Zun-You, MAO  Li-Jun, CHEN  Jia-Cun   

  1. Department of Urology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, China
  • Online:2011-10-08 Published:2011-09-27

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摘要： 溶瘤病毒是一类仅在肿瘤细胞内特异增殖的新型病毒载体，具有高度的肿瘤靶向性和良好的转染率。局部注射溶瘤病毒治疗体表肿瘤已获得显著疗效，但全身应用后机体的免疫防御机制明显限制了溶瘤病毒的治疗效果。细胞荷载溶瘤病毒可能是克服这一瓶颈的有效策略，为治疗肿瘤提供了新的平台。

关键词: font-size: 12pt, mso-bidi-font-family: 'Times New Roman', mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">溶瘤病毒color: black, font-size: 12pt, mso-bidi-font-family: 'Times New Roman', mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-bidi-font-size: 10.0pt">, 肿瘤, font-size: 12pt, mso-bidi-font-family: 'Times New Roman', mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-font-kerning: 1.0pt, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">治疗

Abstract: Oncolytic viruses, a novel class of virus vectors, which selectively replicate only in tumor cells, have excellent tumor targeting and good tansfection efficiency. Many oncolytic viruses have apparent curative effect when administered intratumorally. However, the host immune system remains a critical obstacle to systemic administration of virotherapeutics. It appears that cell-based delivery of oncolytic viruses could offer one solution to this critical problem, which provides a new platform to the biological therapy of cancer.

Key words: font-size: 12pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt, mso-fareast-font-family: 宋体" lang="EN-US">Oncolytic viruses, Neoplasms, Therapy