国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (5): 296-299.doi: 10.3760/cma.j.issn.1673422X.2018.05.010

• 综述 • 上一篇    下一篇

髓样分化因子88在肿瘤中的作用机制

范嫣,相芬芬,陈自喜,康向东,吴蓉   

  1. 200333 上海中医药大学附属普陀医院检验科
  • 出版日期:2018-05-08 发布日期:2018-05-23
  • 通讯作者: 吴蓉,Email: rong701@126.com E-mail:rong701@126.com
  • 基金资助:

    国家自然科学基金（81703878）

Mechanism of myeloid differentiation factor 88 in tumor

Fan Yan, Xiang Fenfen, Chen Zixi, Kang Xiangdong, Wu Rong   

  1.  Department of Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200333, China
  • Online:2018-05-08 Published:2018-05-23
  • Contact: Wu Rong E-mail:rong701@126.com
  • Supported by:

    National Natural Science Foundation of China (81703878)

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摘要： 髓样分化因子88（MyD88）在肿瘤的发生、发展及其恶变中都起着重要的作用，并参与肿瘤的微环境、增殖凋亡、侵袭转移、肿瘤耐药等作用。MyD88有可能作为一个新的有意义的治疗靶点，通过调控多个信号通路促进肿瘤的发生发展、加强肿瘤细胞的耐药作用。

关键词: 肿瘤, 髓样分化因子88

Abstract: Myeloid differentiation factor 88 (MyD88) plays an important role in tumorigenesis, development and malignant transformation, also participates in the microenvironment, proliferation, apoptosis, invasion, metastasis and tumor resistance. MyD88 may serve as a new and meaningful therapeutic target, which can promote the growth and development of tumors by regulating multiple signaling pathways and enhance the drug resistance of tumor cells.

Key words: Neoplasms, Myeloid differentiation factor 88