国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 686-688.doi: 10.3760/cma.j.issn.1673422X.2017.09.011

• 综述 • 上一篇    下一篇

治疗性肿瘤疫苗的研究进展

张百红,岳红云   

  1. 730050 兰州军区兰州总医院肿瘤科（张百红）,眼科（岳红云）
  • 出版日期:2017-09-08 发布日期:2017-10-31
  • 通讯作者: 张百红，Email： bhzhang1999@126.com E-mail: bhzhang1999@126.com
  • 基金资助:

    甘肃省自然科学基金（1308RJZA181）

Advances of therapeutic cancer vaccines

Zhang Baihong, Yue Hongyun   

  1. Department of Oncology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou 730050, China
  • Online:2017-09-08 Published:2017-10-31
  • Contact: Zhang Baihong E-mail: bhzhang1999@126.com
  • Supported by:

    Natural Science Foundation of Gansu Province of China (1308RJZA181)

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被引次数

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摘要： 治疗性肿瘤疫苗为肿瘤免疫治疗提供了新的方法。肿瘤抗原激活T细胞反应是肿瘤疫苗的作用机制，但又因缺乏特异性抗原而使其疗效受到影响。肿瘤疫苗主要来源于抗原肽段疫苗、树突状细胞疫苗和融瘤病毒疫苗。发展个体化疫苗是肿瘤疫苗的发展方向。

关键词: 肿瘤, 免疫疗法, 癌症疫苗

Abstract: Therapeutic cancer vaccines offer a novel avenue for the development of cancer immunotherapy. Tumor antigens can induce T cell antitumor immune responses, but lack of tumorspecific antigens has hampered clinical efficacy. Vaccine types include peptide vaccines, dendritic cell vaccines and oncolytic virus vaccines. Personalizing tumor vaccines may provide a new immunotherapeutic strategy to treat cancer.

Key words: Neoplasms, Immunotherapy, Cancer vaccines