国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 133-135.doi: 10.3760/cma.j.issn.1673422X.2017.02.014

• 综述 • 上一篇    下一篇

肿瘤的精准化疗

张百红, 岳红云   

  1. 730050 兰州军区兰州总医院肿瘤科（张百红）,眼科（岳红云）
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 张百红，Email： bhzhang1999@126.com E-mail:bhzhang1999@126.com
  • 基金资助:

    甘肃省自然科学基金（1308RJZA181）

Precision chemotherapy for the treatment of cancers

Department of Oncology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou 730050, China   

  1. Department of Oncology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou 730050, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Zhang Baihong E-mail:bhzhang1999@126.com
  • Supported by:

    Natural Science Foundation of Gansu Province of China （1308RJZA181）

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摘要： 根据化疗相关基因选择合适的化疗方案从而实现精准化疗是未来肿瘤化疗的方向。化疗相关基因包括DNA修复基因、药物代谢酶、药物转运蛋白、凋亡相关基因和肿瘤相关基因，这些基因可预测抗肿瘤药物的疗效和毒性，并能判定临床预后的情况。

关键词: 肿瘤, 药物疗法, 精准医学

Abstract: Precision chemotherapy is the prospective direction of cancer chemotherapy, which involves the selection of the effective chemotherapy regimens based on the chemotherapyrelated genes. Chemotherapyrelated genes include DNA repair genes, drug metabolism enzymes, drug transporters, apoptosisrelated genes and cancerrelated genes. These genes can predict the response and toxicity of chemotherapy, and determine the clinical outcome.

Key words: Neoplasms, Drug therapy, Precision Medicine