国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 125-128.doi: 10.3760/cma.j.issn.1673422X.2017.02.012

• 综述 • 上一篇    下一篇

 癌相关成纤维细胞的分化来源

董熠,姚颐,宋启斌,李营歌   

  1. 430060 武汉大学人民医院肿瘤中心
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 姚颐，Email: yiyaowhu@qq.com E-mail:yiyaowhu@qq.com
  • 基金资助:

    国家自然科学基金（81372407）

Differentiation origins of cancer associated fibroblast

Dong Yi, Yao Yi, Song Qibin, Li Yingge   

  1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Yao Yi E-mail:yiyaowhu@qq.com
  • Supported by:

    National Natural Science Foundation of China (81372407)

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摘要： 癌相关成纤维细胞（CAF）是肿瘤微环境重要的组成部分，甚至有研究者提出CAF可能作为抗肿瘤治疗的新靶点。然而研究的难点在于CAF分化来源的多样性，包括宿主成纤维细胞、上皮细胞、内皮细胞、间质细胞和干细胞等，而不同的来源决定了CAF不同的表型和功能。全面了解CAF的分化来源，将为抗肿瘤治疗提供新思路。

关键词: 肿瘤, 细胞分化, 癌相关成纤维细胞, 肿瘤微环境

Abstract: Cancer associated fibroblast (CAF) is the most important component in the tumor environment, and some researchers even propose that CAF can be the new target in cancer therapy. However what make it difficult for researchers are the various origins of the CAF, such as resident fibroblast, epithelium, endotheliocyte, mesenchymal cell, stem cell and so on. The various origins define their different phenotypes and functions. Further understanding about the origins of the CAF will help us to explore a novel approach for cancer therapy.

Key words: Neoplasms, Cell differentiation, Cancer associated fibroblasts, Tumor microenvironment