国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (11): 835-837.doi: 10.3760/cma.j.issn.1673422X.2015.11.010

• 综述 • 上一篇    下一篇

一元羧酸转运子1在肿瘤中的表达及作用  

 邰闪闪,王娟,程斌   

  1. 510055 广州，中山大学光华口腔医学院附属口腔医院黏膜科 广东省口腔重点实验室
  • 出版日期:2015-11-08 发布日期:2015-09-30
  • 通讯作者: 程斌，Email: chengbin@mail.sysu.edu.cn E-mail:chengbin@mail.sysu.edu.cn
  • 基金资助:

    国家自然科学基金（81272948）

The expression and role of monocarboxylate transporter 1 in tumor

Tai Shanshan, Wang Juan, Cheng Bin.   

  1. Department of Oral Medicine, Guanghua School of Stomatology, Sun Yatsen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Cheng Bin E-mail:chengbin@mail.sysu.edu.cn

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摘要： 一元羧酸转运子（MCT）家族在肿瘤代谢中发挥重要作用，其中MCT1对一元羧酸的转运作用最显著。MCT1介导多种一元羧酸跨膜转运，可以根据代谢状态决定摄取或排出乳酸，从而维持肿瘤细胞的特殊代谢模式。综合分析MCT1与肿瘤的生长、代谢、侵袭和转移的关系，MCT1有望成为肿瘤治疗的新靶点。

关键词: 肿瘤, 代谢, 一元羧酸转运子1

Abstract: The monocarboxylate transporters (MCTs) family, especially MCT1, plays an important role in tumor metabolism. MCT1 mediates a variety of monocarboxylic acids across the plasma membrane, and determines to take in or export lactic acid according to the metabolic state, thus maintaining the special tumor cells metabolism model. Considering the emerging evidence for the role of MCT1 in the tumor genesis, metabolism, invasion and metastasis, MCT1 is expected to be a new target for cancer therapy. 【Key words】Neoplasms; Metabolism; Monocarboxylate transporter 1

Key words: Neoplasms, Metabolism, Monocarboxylate transporter 1