国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 500-502.doi: 10.3760/cma.j.issn.1673422X.2014.07.006

• 综述 • 上一篇    下一篇

着丝粒蛋白F与恶性肿瘤的关系

郑瑾,林英城   

  1. 515031 汕头大学医学院附属肿瘤医院内科
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 林英城，Email: linyingcheng@medmail.com.cn E-mail:linyingcheng@medmail.com.cn

Research progress of kinetochore protein CENPF in malignant tumor

 ZHENG  Jin, LIN  Ying-Cheng   

  1. Department of Medical Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Lin Yingcheng E-mail:linyingcheng@medmail.com.cn

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摘要： 着丝粒蛋白F(CENPF)是细胞周期依赖性的着丝粒蛋白，其表达和定位具有严格的细胞周期性。CENPF在肿瘤发生中起重要作用。CENPF在多种肿瘤中表达上调，是重要的细胞增殖标志物，研究显示与肿瘤的发生、发展、侵袭、复发与预后等相关，是一个有价值的肿瘤预后指标和潜在治疗靶点。

关键词: 肿瘤, 预后, 着丝粒蛋白F

Abstract: CENPF is a cellcycle dependent kinetochore protein, whose expression and localization patterns are regulated in a cell cycledependent manner. CENPF plays an important role in the development and progress of malignant tumor. The expression of CENPF is upregulated in many tumors. It serves as an important marker in cell proliferation. Studies have demonstrated that CENPF is involved in tumor genesis, progress, invasiveness, relapse and prognosis. CENPF might be a valuable prognostic marker and potential therapy target in cancer treatment.

Key words: Neoplasms, Prognosis, Centromere protein F