Krüppel样因子在肝癌中的研究进展

doi:10.3760/cma.j.issn.1673-422X.2020.02.012

国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (2): 119-122.doi: 10.3760/cma.j.issn.1673-422X.2020.02.012

Krüppel样因子在肝癌中的研究进展

赵传喜¹, 朱婷婷¹, 刘明国², 曹莉莉^1,³()

1 山东第一医科大学第一附属医院(山东省千佛山医院)肿瘤科山东第一医科大学(山东省医学科学院),济南 250014
2 山东省菏泽市郓城诚信医院内二科 274700
3 山东第一医科大学第一附属医院(山东省千佛山医院)山东省风湿免疫病转化医学重点实验室,济南 250014

收稿日期:2019-12-13 修回日期:2020-01-13 出版日期:2020-02-08 发布日期:2020-05-27
通讯作者: 曹莉莉 E-mail:cllly22@163.com

Advances of Krüppel-like factors in hepatocellular carcinoma

Zhao Chuanxi¹, Zhu Tingting¹, Liu Mingguo², Cao Lili^1,³()

1 Department of Oncology, First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250014, China
2 Second Department of Internal Medicine, Yuncheng Chengxin Hospital of Heze City of Shandong Province, Yuncheng 274700, China
3 Shandong Provincial Key Laboratory for Rheumatic Immunity Disease and Translational Medicine, First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan 250014, China

Received:2019-12-13 Revised:2020-01-13 Online:2020-02-08 Published:2020-05-27
Contact: Cao Lili E-mail:cllly22@163.com

摘要/Abstract

摘要：

Krüppel样因子(KLF)在肿瘤的发生发展中发挥极其重要的作用,同时KLF家族被证实影响肝癌细胞的增殖、分化和迁移。KLF家族中有9名成员(KLF2、KLF4、KLF5、KLF6、KLF8、KLF9、KLF10、KLF14和KLF17)可作为癌基因或抑癌基因以多种方式参与肝癌的发生发展,并有望成为肝癌的生物学治疗靶点。

关键词: 肝肿瘤, 基因,肿瘤抑制, 癌基因, Krüppel样因子

Abstract:

Krüppel-like factors (KLFs) play extremely important roles in genesis and development of tumors. Simultaneously, KLFs have been proven to affect the proliferation, differentiation and migration of hepatocellular carcinoma cells. Nine members in the KLFs family (KLF2, KLF4, KLF5, KLF6, KLF8, KLF9, KLF10, KLF14 and KLF17) are involved in the occurrence and development of hepatocellular carcinoma in various ways as an oncogene and tumor suppressor gene. Therefore, the KLFs family will hopefully become biological therapeutic targets for hepatocellular carcinoma.

Key words: Liver neoplasms, Genes, tumor suppressor, Oncogene, Krüppel-like factors

赵传喜, 朱婷婷, 刘明国, 曹莉莉. Krüppel样因子在肝癌中的研究进展[J]. 国际肿瘤学杂志, 2020, 47(2): 119-122.

Zhao Chuanxi, Zhu Tingting, Liu Mingguo, Cao Lili. Advances of Krüppel-like factors in hepatocellular carcinoma[J]. Journal of International Oncology, 2020, 47(2): 119-122.

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Krüppel样因子在肝癌中的研究进展

Advances of Krüppel-like factors in hepatocellular carcinoma

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